Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in pathologic processes needs further elucidation. Depending on the cell context, GAPDH may bind a number of physiologically important proteins, c...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/5/416 |
| _version_ | 1797568988844130304 |
|---|---|
| author | Vladimir F. Lazarev Irina V. Guzhova Boris A. Margulis |
| author_facet | Vladimir F. Lazarev Irina V. Guzhova Boris A. Margulis |
| author_sort | Vladimir F. Lazarev |
| collection | DOAJ |
| description | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in pathologic processes needs further elucidation. Depending on the cell context, GAPDH may bind a number of physiologically important proteins, control their function and correspondingly affect the cell’s fate. These interprotein interactions and post-translational modifications of GAPDH mediate its cytotoxic or cytoprotective functions in the manner of a Janus-like molecule. In this review, we discuss the functional features of the enzyme in cellular physiology and its possible involvement in human pathologies. In the last part of the article, we describe drugs that can be employed to modulate this enzyme’s function in some pathologic states. |
| first_indexed | 2024-03-10T20:04:33Z |
| format | Article |
| id | doaj.art-7ea24b84dcf24aed9615225da79db938 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:04:33Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7ea24b84dcf24aed9615225da79db9382023-11-19T23:20:41ZengMDPI AGPharmaceutics1999-49232020-05-0112541610.3390/pharmaceutics12050416Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic TargetVladimir F. Lazarev0Irina V. Guzhova1Boris A. Margulis2Institute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, RussiaInstitute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, RussiaInstitute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, RussiaGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a glycolytic enzyme whose role in cell metabolism and homeostasis is well defined, while its function in pathologic processes needs further elucidation. Depending on the cell context, GAPDH may bind a number of physiologically important proteins, control their function and correspondingly affect the cell’s fate. These interprotein interactions and post-translational modifications of GAPDH mediate its cytotoxic or cytoprotective functions in the manner of a Janus-like molecule. In this review, we discuss the functional features of the enzyme in cellular physiology and its possible involvement in human pathologies. In the last part of the article, we describe drugs that can be employed to modulate this enzyme’s function in some pathologic states.https://www.mdpi.com/1999-4923/12/5/416GAPDHdrugsneurodegenerative diseasescancerdiabeticstreatment |
| spellingShingle | Vladimir F. Lazarev Irina V. Guzhova Boris A. Margulis Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target Pharmaceutics GAPDH drugs neurodegenerative diseases cancer diabetics treatment |
| title | Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target |
| title_full | Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target |
| title_fullStr | Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target |
| title_full_unstemmed | Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target |
| title_short | Glyceraldehyde-3-phosphate Dehydrogenase Is a Multifaceted Therapeutic Target |
| title_sort | glyceraldehyde 3 phosphate dehydrogenase is a multifaceted therapeutic target |
| topic | GAPDH drugs neurodegenerative diseases cancer diabetics treatment |
| url | https://www.mdpi.com/1999-4923/12/5/416 |
| work_keys_str_mv | AT vladimirflazarev glyceraldehyde3phosphatedehydrogenaseisamultifacetedtherapeutictarget AT irinavguzhova glyceraldehyde3phosphatedehydrogenaseisamultifacetedtherapeutictarget AT borisamargulis glyceraldehyde3phosphatedehydrogenaseisamultifacetedtherapeutictarget |