Protein adduction causes non-mutational inhibition of p53 tumor suppressor

Protein adduction causes non-mutational inhibition of p53 tumor suppressor

Summary: p53 is a key tumor suppressor that is frequently mutated in human tumors. In this study, we investigated how p53 is regulated in precancerous lesions prior to mutations in the p53 gene. Analyzing esophageal cells in conditions of genotoxic stress that promotes development of esophageal aden...

Full description

Bibliographic Details
Main Authors: Ravindran Caspa Gokulan, Kodisundaram Paulrasu, Jamal Azfar, Wael El-Rifai, Jianwen Que, Olivier G. Boutaud, Yuguang Ban, Zhen Gao, Monica Garcia Buitrago, Sergey I. Dikalov, Alexander I. Zaika
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723000359

Similar Items

Similar Items