Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus
BackgroundThe ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral den...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1035853/full |
| _version_ | 1811250916998774784 |
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| author | Ting Gao Fupeng Liu Bo Ban Yue Hou Guangxin Li Mingming Jiang Qing Yang Mei Zhang |
| author_facet | Ting Gao Fupeng Liu Bo Ban Yue Hou Guangxin Li Mingming Jiang Qing Yang Mei Zhang |
| author_sort | Ting Gao |
| collection | DOAJ |
| description | BackgroundThe ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodThis cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.ResultsPearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (r = 0.170, p = 0.001), FN (r = 0.178, p < 0.001), and TH (r = 0.205, p < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, p = 0.01; FN: β = 0.097, p = 0.038; TH: β = 0.145, p = 0.002).ConclusionIn older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis. |
| first_indexed | 2024-04-12T16:11:56Z |
| format | Article |
| id | doaj.art-7ea55529f9e4423281b77e1397172571 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T16:11:56Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-7ea55529f9e4423281b77e13971725712022-12-22T03:25:53ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-10-01910.3389/fnut.2022.10358531035853Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitusTing Gao0Fupeng Liu1Bo Ban2Yue Hou3Guangxin Li4Mingming Jiang5Qing Yang6Mei Zhang7Department of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Clinical Medicine, Jining Medical University, Jining, Shandong, ChinaDepartment of Nutrition, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaBackgroundThe ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodThis cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.ResultsPearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (r = 0.170, p = 0.001), FN (r = 0.178, p < 0.001), and TH (r = 0.205, p < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, p = 0.01; FN: β = 0.097, p = 0.038; TH: β = 0.145, p = 0.002).ConclusionIn older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.https://www.frontiersin.org/articles/10.3389/fnut.2022.1035853/fulltype 2 diabetescreatininecystatin CCre/CysCbone mineral density |
| spellingShingle | Ting Gao Fupeng Liu Bo Ban Yue Hou Guangxin Li Mingming Jiang Qing Yang Mei Zhang Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus Frontiers in Nutrition type 2 diabetes creatinine cystatin C Cre/CysC bone mineral density |
| title | Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus |
| title_full | Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus |
| title_fullStr | Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus |
| title_short | Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus |
| title_sort | association between the ratio of serum creatinine to cystatin c and bone mineral density in chinese older adults patients with type 2 diabetes mellitus |
| topic | type 2 diabetes creatinine cystatin C Cre/CysC bone mineral density |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1035853/full |
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