Acute hepatitis of unknown aetiology among children around the world
Abstract By 26 August 2022, the number of cases of acute hepatitis of unknown etiology (AHUA) has drastically increased to 1115 distributed in 35 countries that fulfill the World Health Organization definition. Several hypotheses on the cause of AHUA have been proposed and are being investigated aro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Infectious Diseases of Poverty |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40249-022-01035-2 |
| _version_ | 1828309222432964608 |
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| author | Chao Wang Zhi-Yong Gao Nick Walsh Stephen Hadler Qing-Bin Lu Fuqiang Cui |
| author_facet | Chao Wang Zhi-Yong Gao Nick Walsh Stephen Hadler Qing-Bin Lu Fuqiang Cui |
| author_sort | Chao Wang |
| collection | DOAJ |
| description | Abstract By 26 August 2022, the number of cases of acute hepatitis of unknown etiology (AHUA) has drastically increased to 1115 distributed in 35 countries that fulfill the World Health Organization definition. Several hypotheses on the cause of AHUA have been proposed and are being investigated around the world. In the recent United Kingdom (UK) report, human adenovirus (HAdV) with adeno-associated virus (AAV) co-infection is the leading hypothesis. However, there is still limited evidence in establishing the causal relationship between AHUA and any potential aetiology. The leading aetiology continues to be HAdV infection. It is reported that HAdV genomics is not unusual among the population in the UK, especially among AUHA cases. Expanding the surveillance of HAdV and AAV in the population and the environment in the countries with AUHA cases is suggested to be the primary action. Metagenomics should be used in detecting other infectious pathogens on a larger scale, to supplement the detection of viruses in the blood, stool, and liver specimens from AUHA cases. It is useful to develop a consensus-specific case definition of AHUA to better understand the characteristics of these cases globally based on all the collected cases. |
| first_indexed | 2024-04-13T15:26:53Z |
| format | Article |
| id | doaj.art-7ea8eb0ed3454fdcaa71f62615e9dc77 |
| institution | Directory Open Access Journal |
| issn | 2049-9957 |
| language | English |
| last_indexed | 2024-04-13T15:26:53Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Diseases of Poverty |
| spelling | doaj.art-7ea8eb0ed3454fdcaa71f62615e9dc772022-12-22T02:41:30ZengBMCInfectious Diseases of Poverty2049-99572022-11-011111610.1186/s40249-022-01035-2Acute hepatitis of unknown aetiology among children around the worldChao Wang0Zhi-Yong Gao1Nick Walsh2Stephen Hadler3Qing-Bin Lu4Fuqiang Cui5Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking UniversityInstitute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control and Beijing Research Center for Preventive MedicineDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash UniversityIndependent Consultant, Medical EpidemiologyDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking UniversityDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking UniversityAbstract By 26 August 2022, the number of cases of acute hepatitis of unknown etiology (AHUA) has drastically increased to 1115 distributed in 35 countries that fulfill the World Health Organization definition. Several hypotheses on the cause of AHUA have been proposed and are being investigated around the world. In the recent United Kingdom (UK) report, human adenovirus (HAdV) with adeno-associated virus (AAV) co-infection is the leading hypothesis. However, there is still limited evidence in establishing the causal relationship between AHUA and any potential aetiology. The leading aetiology continues to be HAdV infection. It is reported that HAdV genomics is not unusual among the population in the UK, especially among AUHA cases. Expanding the surveillance of HAdV and AAV in the population and the environment in the countries with AUHA cases is suggested to be the primary action. Metagenomics should be used in detecting other infectious pathogens on a larger scale, to supplement the detection of viruses in the blood, stool, and liver specimens from AUHA cases. It is useful to develop a consensus-specific case definition of AHUA to better understand the characteristics of these cases globally based on all the collected cases.https://doi.org/10.1186/s40249-022-01035-2Acute hepatitisAetiologyChildrenDisease surveillance |
| spellingShingle | Chao Wang Zhi-Yong Gao Nick Walsh Stephen Hadler Qing-Bin Lu Fuqiang Cui Acute hepatitis of unknown aetiology among children around the world Infectious Diseases of Poverty Acute hepatitis Aetiology Children Disease surveillance |
| title | Acute hepatitis of unknown aetiology among children around the world |
| title_full | Acute hepatitis of unknown aetiology among children around the world |
| title_fullStr | Acute hepatitis of unknown aetiology among children around the world |
| title_full_unstemmed | Acute hepatitis of unknown aetiology among children around the world |
| title_short | Acute hepatitis of unknown aetiology among children around the world |
| title_sort | acute hepatitis of unknown aetiology among children around the world |
| topic | Acute hepatitis Aetiology Children Disease surveillance |
| url | https://doi.org/10.1186/s40249-022-01035-2 |
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