<i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging
Oxidative stress plays a major role in the skin aging process through the reactive oxygen species production and advanced glycation end products (AGEs) formation. Antioxidant ingredients are therefore needed in the skin care market and the use of molecules coming from plant cell cultures provide a u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/12/2409 |
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| author | Sara Ceccacci Adriana De Lucia Assunta Tortora Antonio Colantuono Gennaro Carotenuto Annalisa Tito Maria Chiara Monti |
| author_facet | Sara Ceccacci Adriana De Lucia Assunta Tortora Antonio Colantuono Gennaro Carotenuto Annalisa Tito Maria Chiara Monti |
| author_sort | Sara Ceccacci |
| collection | DOAJ |
| description | Oxidative stress plays a major role in the skin aging process through the reactive oxygen species production and advanced glycation end products (AGEs) formation. Antioxidant ingredients are therefore needed in the skin care market and the use of molecules coming from plant cell cultures provide a unique opportunity. In this paper, the features of an hydroethanolic extract obtained by <i>Jasminum sambac</i> cells (JasHEx) were explored. The antioxidant and anti-AGE properties were investigated by a multidisciplinary approach combining mass spectrometric and bio-informatic in vitro and ex vivo experiments. JasHEx contains phenolic acid derivatives, lignans and triterpenes and it was found to reduce cytosolic reactive oxygen species production in keratinocytes exposed to exogenous stress. It also showed the ability to reduce AGE formation and to increase the collagen type I production in extracellular matrix. Data demonstrated that JasHEx antioxidant properties were related to its free radical scavenging and metal chelating activities and to the activation of the Nrf2/ARE pathway. This can well explain JasHEx anti-inflammatory activity related to the decrease in NO levels in LPS-stimulated macrophages. Thus, JasHEx can be considered a powerful antioxidant booster against oxidative stress-induced skin aging. |
| first_indexed | 2024-03-09T17:23:07Z |
| format | Article |
| id | doaj.art-7ea9dbd097bd4f6ab573ec9f95670d1e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T17:23:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-7ea9dbd097bd4f6ab573ec9f95670d1e2023-11-24T12:57:35ZengMDPI AGAntioxidants2076-39212022-12-011112240910.3390/antiox11122409<i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin AgingSara Ceccacci0Adriana De Lucia1Assunta Tortora2Antonio Colantuono3Gennaro Carotenuto4Annalisa Tito5Maria Chiara Monti6Department of Pharmacy, University of Salerno, 84084 Fisciano, ItalyArterra Bioscience SpA, 80142 Naples, ItalyArterra Bioscience SpA, 80142 Naples, ItalyArterra Bioscience SpA, 80142 Naples, ItalyArterra Bioscience SpA, 80142 Naples, ItalyArterra Bioscience SpA, 80142 Naples, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, ItalyOxidative stress plays a major role in the skin aging process through the reactive oxygen species production and advanced glycation end products (AGEs) formation. Antioxidant ingredients are therefore needed in the skin care market and the use of molecules coming from plant cell cultures provide a unique opportunity. In this paper, the features of an hydroethanolic extract obtained by <i>Jasminum sambac</i> cells (JasHEx) were explored. The antioxidant and anti-AGE properties were investigated by a multidisciplinary approach combining mass spectrometric and bio-informatic in vitro and ex vivo experiments. JasHEx contains phenolic acid derivatives, lignans and triterpenes and it was found to reduce cytosolic reactive oxygen species production in keratinocytes exposed to exogenous stress. It also showed the ability to reduce AGE formation and to increase the collagen type I production in extracellular matrix. Data demonstrated that JasHEx antioxidant properties were related to its free radical scavenging and metal chelating activities and to the activation of the Nrf2/ARE pathway. This can well explain JasHEx anti-inflammatory activity related to the decrease in NO levels in LPS-stimulated macrophages. Thus, JasHEx can be considered a powerful antioxidant booster against oxidative stress-induced skin aging.https://www.mdpi.com/2076-3921/11/12/2409skin agingreactive oxygen species (ROS)advanced glycation end products (AGEs)<i>Jasminum sambac</i> hydroethanolic extract (JasHEx)mass spectrometrymetabolomics |
| spellingShingle | Sara Ceccacci Adriana De Lucia Assunta Tortora Antonio Colantuono Gennaro Carotenuto Annalisa Tito Maria Chiara Monti <i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging Antioxidants skin aging reactive oxygen species (ROS) advanced glycation end products (AGEs) <i>Jasminum sambac</i> hydroethanolic extract (JasHEx) mass spectrometry metabolomics |
| title | <i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging |
| title_full | <i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging |
| title_fullStr | <i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging |
| title_full_unstemmed | <i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging |
| title_short | <i>Jasminum sambac</i> Cell Extract as Antioxidant Booster against Skin Aging |
| title_sort | i jasminum sambac i cell extract as antioxidant booster against skin aging |
| topic | skin aging reactive oxygen species (ROS) advanced glycation end products (AGEs) <i>Jasminum sambac</i> hydroethanolic extract (JasHEx) mass spectrometry metabolomics |
| url | https://www.mdpi.com/2076-3921/11/12/2409 |
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