Metabolic risks in living kidney donors in South Korea
Background Considering the growing prevalence of Western lifestyles and related chronic diseases occurring in South Korea, this study aimed to explore the progression of metabolic risk factors in living kidney donors. Methods This study enrolled living kidney donors from seven hospitals from 1982 to...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2021-12-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-20-271.pdf |
| _version_ | 1811311924524089344 |
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| author | Eunjeong Kang Jina Park Hyo Jeong Kim Sehoon Park Minsu Park Yaerim Kim Kwangsoo Kim Sang Min Park Dong-Wan Chae Ho Jun Chin Jung Pyo Lee Sik Lee Soo Wan Kim Jang-Hee Cho Miyeun Han Yong Chul Kim Yon Su Kim Insun Choi Hajeong Lee |
| author_facet | Eunjeong Kang Jina Park Hyo Jeong Kim Sehoon Park Minsu Park Yaerim Kim Kwangsoo Kim Sang Min Park Dong-Wan Chae Ho Jun Chin Jung Pyo Lee Sik Lee Soo Wan Kim Jang-Hee Cho Miyeun Han Yong Chul Kim Yon Su Kim Insun Choi Hajeong Lee |
| author_sort | Eunjeong Kang |
| collection | DOAJ |
| description | Background Considering the growing prevalence of Western lifestyles and related chronic diseases occurring in South Korea, this study aimed to explore the progression of metabolic risk factors in living kidney donors. Methods This study enrolled living kidney donors from seven hospitals from 1982 to 2016. The controls were individuals that voluntarily received health check-ups from 1995 to 2016 that were matched with donors according to age, sex, diabetes status, baseline estimated glomerular filtration rate, and date of the medical record. Data on hyperuricemia, hypertension, hypercholesterolemia, and overweight/obesity were collected to determine metabolic risks. Logistic regressions with interaction terms between the medical record date and donor status were used to compare the trends in metabolic risks over time in the two groups. Results A total of 2,018 living kidney donors and matched non-donors were included. The median age was 44.0 years and 54.0% were women. The living kidney donors showed a lower absolute prevalence for all metabolic risk factors, except for those that were overweight/obese, than the non-donors. The proportion of subjects that were overweight/obese was consistently higher over time in the donor group. The changes over time in the prevalence of each metabolic risk were not significantly different between groups, except for a lower prevalence of metabolic risk factors ≥ 3 in donors. Conclusion Over time, metabolic risks in living kidney donors are generally the same as in non-donors, except for a lower prevalence of metabolic risk factors ≥3 in donors. |
| first_indexed | 2024-04-13T10:27:28Z |
| format | Article |
| id | doaj.art-7eab713551ab44cd8c34f8b8b0bc2f57 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-13T10:27:28Z |
| publishDate | 2021-12-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-7eab713551ab44cd8c34f8b8b0bc2f572022-12-22T02:50:16ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402021-12-0140464565910.23876/j.krcp.20.2716062Metabolic risks in living kidney donors in South KoreaEunjeong Kang0Jina Park1Hyo Jeong Kim2Sehoon Park3Minsu Park4Yaerim Kim5Kwangsoo Kim6Sang Min Park7Dong-Wan Chae8Ho Jun Chin9Jung Pyo Lee10Sik Lee11Soo Wan Kim12Jang-Hee Cho13Miyeun Han14Yong Chul Kim15Yon Su Kim16Insun Choi17Hajeong Lee18 Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Statistics, Keimyung University, Daegu, Republic of Korea Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Republic of Korea Department of Family Medicine, Seoul National University Hospital, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Republic of Korea Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea Department of Internal Medicine, Kyungpook National University, Daegu, Republic of Korea Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaBackground Considering the growing prevalence of Western lifestyles and related chronic diseases occurring in South Korea, this study aimed to explore the progression of metabolic risk factors in living kidney donors. Methods This study enrolled living kidney donors from seven hospitals from 1982 to 2016. The controls were individuals that voluntarily received health check-ups from 1995 to 2016 that were matched with donors according to age, sex, diabetes status, baseline estimated glomerular filtration rate, and date of the medical record. Data on hyperuricemia, hypertension, hypercholesterolemia, and overweight/obesity were collected to determine metabolic risks. Logistic regressions with interaction terms between the medical record date and donor status were used to compare the trends in metabolic risks over time in the two groups. Results A total of 2,018 living kidney donors and matched non-donors were included. The median age was 44.0 years and 54.0% were women. The living kidney donors showed a lower absolute prevalence for all metabolic risk factors, except for those that were overweight/obese, than the non-donors. The proportion of subjects that were overweight/obese was consistently higher over time in the donor group. The changes over time in the prevalence of each metabolic risk were not significantly different between groups, except for a lower prevalence of metabolic risk factors ≥ 3 in donors. Conclusion Over time, metabolic risks in living kidney donors are generally the same as in non-donors, except for a lower prevalence of metabolic risk factors ≥3 in donors.http://www.krcp-ksn.org/upload/pdf/j-krcp-20-271.pdfhypercholesterolemiahyperuricemiakidney transplantationliving donorsrisk factors |
| spellingShingle | Eunjeong Kang Jina Park Hyo Jeong Kim Sehoon Park Minsu Park Yaerim Kim Kwangsoo Kim Sang Min Park Dong-Wan Chae Ho Jun Chin Jung Pyo Lee Sik Lee Soo Wan Kim Jang-Hee Cho Miyeun Han Yong Chul Kim Yon Su Kim Insun Choi Hajeong Lee Metabolic risks in living kidney donors in South Korea Kidney Research and Clinical Practice hypercholesterolemia hyperuricemia kidney transplantation living donors risk factors |
| title | Metabolic risks in living kidney donors in South Korea |
| title_full | Metabolic risks in living kidney donors in South Korea |
| title_fullStr | Metabolic risks in living kidney donors in South Korea |
| title_full_unstemmed | Metabolic risks in living kidney donors in South Korea |
| title_short | Metabolic risks in living kidney donors in South Korea |
| title_sort | metabolic risks in living kidney donors in south korea |
| topic | hypercholesterolemia hyperuricemia kidney transplantation living donors risk factors |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-20-271.pdf |
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