Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse

Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse

There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towar...

Full description

Bibliographic Details
Main Authors: Thiago S. Machado, Carolina H. Macabelli, Maite Del Collado, Flávio V. Meirelles, Francisco E. G. Guimarães, Marcos R. Chiaratti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Genetics
Subjects:
mitochondria
embryo
mitochondrial DNA
mtDNA
mouse
cytoplasmic transfer
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00762/full

Similar Items

Similar Items