A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation
Plasma cells are terminally differentiated B cells that are specialized for antibody secretion. Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34969-0 |
| _version_ | 1811315543174545408 |
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| author | Jianfeng Wu Kang Yang Shaowei Cai Xiaohan Zhang Lichen Hu Fanjia Lin Su-qin Wu Changchun Xiao Wen-Hsien Liu Jiahuai Han |
| author_facet | Jianfeng Wu Kang Yang Shaowei Cai Xiaohan Zhang Lichen Hu Fanjia Lin Su-qin Wu Changchun Xiao Wen-Hsien Liu Jiahuai Han |
| author_sort | Jianfeng Wu |
| collection | DOAJ |
| description | Plasma cells are terminally differentiated B cells that are specialized for antibody secretion. Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional regulatory program by BLIMP1. |
| first_indexed | 2024-04-13T11:31:54Z |
| format | Article |
| id | doaj.art-7eacb188fa0445489b0d57415f695ccf |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T11:31:54Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7eacb188fa0445489b0d57415f695ccf2022-12-22T02:48:32ZengNature PortfolioNature Communications2041-17232022-11-0113112010.1038/s41467-022-34969-0A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiationJianfeng Wu0Kang Yang1Shaowei Cai2Xiaohan Zhang3Lichen Hu4Fanjia Lin5Su-qin Wu6Changchun Xiao7Wen-Hsien Liu8Jiahuai Han9State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityLaboratory animal research center, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen UniversityPlasma cells are terminally differentiated B cells that are specialized for antibody secretion. Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional regulatory program by BLIMP1.https://doi.org/10.1038/s41467-022-34969-0 |
| spellingShingle | Jianfeng Wu Kang Yang Shaowei Cai Xiaohan Zhang Lichen Hu Fanjia Lin Su-qin Wu Changchun Xiao Wen-Hsien Liu Jiahuai Han A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation Nature Communications |
| title | A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation |
| title_full | A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation |
| title_fullStr | A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation |
| title_full_unstemmed | A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation |
| title_short | A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation |
| title_sort | p38α blimp1 signalling pathway is essential for plasma cell differentiation |
| url | https://doi.org/10.1038/s41467-022-34969-0 |
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