OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
Abstract The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues. In inflammatory bowel disease (IBD) in humans, as well as in experimental mouse models of IBD, this barrier is impaired, c...
Main Authors: | Lien Verboom, Christopher J. Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S. Ravichandran, Lars Vereecke, Geert van Loo |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2023-08-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-023-06058-7 |
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