Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study
Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/3/143 |
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| author | Nuri Gueven Kevin J. Spring Sandra Holmes Kiran Ahuja Raj Eri Ah Young Park J Helen Fitton |
| author_facet | Nuri Gueven Kevin J. Spring Sandra Holmes Kiran Ahuja Raj Eri Ah Young Park J Helen Fitton |
| author_sort | Nuri Gueven |
| collection | DOAJ |
| description | Fucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of <i>Undaria pinnatifida</i> fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer-related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function. |
| first_indexed | 2024-04-14T05:26:27Z |
| format | Article |
| id | doaj.art-7eaf9cffc5764eea843429482ed7bb9d |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T05:26:27Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-7eaf9cffc5764eea843429482ed7bb9d2022-12-22T02:09:57ZengMDPI AGMarine Drugs1660-33972020-02-0118314310.3390/md18030143md18030143Micro RNA Expression after Ingestion of Fucoidan; A Clinical StudyNuri Gueven0Kevin J. Spring1Sandra Holmes2Kiran Ahuja3Raj Eri4Ah Young Park5J Helen Fitton6Pharmacy, School of Medicine, University of Tasmania, Hobart, TAS 7001, AustraliaMedical Oncology, Ingham Institute for Applied Medical Research, School of Medicine, Western Sydney University and SWS Clinical School, UNSW, Sydney, NSW 2170, AustraliaPharmacy, School of Medicine, University of Tasmania, Hobart, TAS 7001, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, TAS 7248, AustraliaSchool of Health Sciences, University of Tasmania, Newnham, TAS 7248, AustraliaMarinova Pty Ltd., Cambridge, TAS 7170, AustraliaMarinova Pty Ltd., Cambridge, TAS 7170, AustraliaFucoidans are a class of fucose-rich sulfated polysaccharides derived from brown macroalgae that exert a range of biological activities in vitro and in vivo. To generate an unbiased assessment of pathways and processes affected by fucoidan, a placebo-controlled double-blind pilot study was performed in healthy volunteers. Blood samples were taken immediately before and 24 h after ingestion of a single dose of 1 g of <i>Undaria pinnatifida</i> fucoidan (UPF) or placebo. Levels of isolated miRNAs were analyzed using Taqman Open Array Human MicroRNA panels. Out of 754 miRNAs screened, UPF affected a total of 53 miRNAs. Pathway analysis using the TALOS data analysis tool predicted 29 different pathways and processes that were largely grouped into cell surface receptor signaling, cancer-related pathways, the majority of which were previously associated with fucoidans. However, this analysis also identified nine pathways and processes that have not been associated with fucoidans before. Overall, this study illustrates that even a single dose of fucoidans has the potential to affect the expression of genes related to fundamental cellular processes. Moreover, it confirms previous data that fucoidans influence immunity, cancer cells, inflammation, and neurological function.https://www.mdpi.com/1660-3397/18/3/143fucoidanclinicalmicrorna, anti-inflammatory, anti-cancer |
| spellingShingle | Nuri Gueven Kevin J. Spring Sandra Holmes Kiran Ahuja Raj Eri Ah Young Park J Helen Fitton Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study Marine Drugs fucoidan clinical microrna, anti-inflammatory, anti-cancer |
| title | Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study |
| title_full | Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study |
| title_fullStr | Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study |
| title_full_unstemmed | Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study |
| title_short | Micro RNA Expression after Ingestion of Fucoidan; A Clinical Study |
| title_sort | micro rna expression after ingestion of fucoidan a clinical study |
| topic | fucoidan clinical microrna, anti-inflammatory, anti-cancer |
| url | https://www.mdpi.com/1660-3397/18/3/143 |
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