C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury

C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury

Hypoxic-ischemic neonatal encephalopathy due to perinatal asphyxia is the leading cause of brain injury in newborns. Clinical data suggest that brain inflammation induced by perinatal insults can persist for years. We previously showed that signaling through the receptor for complement peptide C3a (...

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Bibliographic Details
Main Authors: Andrea Pozo-Rodrigálvarez, YiXian Li, Anna Stokowska, Jingyun Wu, Verena Dehm, Hana Sourkova, Harry Steinbusch, Carina Mallard, Henrik Hagberg, Milos Pekny, Marcela Pekna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
developing brain
neonatal encephalopathy
hypoxia-ischemia
complement system: neurodegeneration
reactive gliosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.768198/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.768198/full

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