Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A
Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=92;epage=94;aulast=Lodha |
| _version_ | 1819267310057160704 |
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| author | A Lodha M Lodha A Patel J Chaudhuri J Dalal M Edwards D Douroumis |
| author_facet | A Lodha M Lodha A Patel J Chaudhuri J Dalal M Edwards D Douroumis |
| author_sort | A Lodha |
| collection | DOAJ |
| description | Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and inorganic groups. Silica nano-particles were synthesized by chemical methods from tetraethylorthosilicate (TEOS), methanol (CH3OH) and deionised water in the presence of sodium hydroxide as catalyst at 80°C temperature. The nature and morphology of particles was investigated by scanning electron microscopy (SEM), N2 adsorption/desorption method using BET instrument and X-ray diffraction (XRD). Silica nanoparticles are applicable to a wide range of therapeutic entities from small molecule to peptides and proteins including hydrophobic and hydrophilic entities. Drug loading does not require chemical modification of the molecule; there are no changes in the drug structure or activity after loading and subsequent release of the drug. Thus, well suited to solve formulation problems associated with hydrophobic drugs such as peptide and protein drugs like cyclosporine A. Silica nanoparticles improved the solubility of poorly water soluble drugs and enhanced the absorption and bioavailability of these compounds. |
| first_indexed | 2024-12-23T21:15:08Z |
| format | Article |
| id | doaj.art-7eb0e084ff1a485681d08296535da05b |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-12-23T21:15:08Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-7eb0e084ff1a485681d08296535da05b2022-12-21T17:30:56ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792012-01-0145929410.4103/0975-7406.94153Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin AA LodhaM LodhaA PatelJ ChaudhuriJ DalalM EdwardsD DouroumisMesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and inorganic groups. Silica nano-particles were synthesized by chemical methods from tetraethylorthosilicate (TEOS), methanol (CH3OH) and deionised water in the presence of sodium hydroxide as catalyst at 80°C temperature. The nature and morphology of particles was investigated by scanning electron microscopy (SEM), N2 adsorption/desorption method using BET instrument and X-ray diffraction (XRD). Silica nanoparticles are applicable to a wide range of therapeutic entities from small molecule to peptides and proteins including hydrophobic and hydrophilic entities. Drug loading does not require chemical modification of the molecule; there are no changes in the drug structure or activity after loading and subsequent release of the drug. Thus, well suited to solve formulation problems associated with hydrophobic drugs such as peptide and protein drugs like cyclosporine A. Silica nanoparticles improved the solubility of poorly water soluble drugs and enhanced the absorption and bioavailability of these compounds.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=92;epage=94;aulast=LodhaSilicananoparticlecyclosporine |
| spellingShingle | A Lodha M Lodha A Patel J Chaudhuri J Dalal M Edwards D Douroumis Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A Journal of Pharmacy and Bioallied Sciences Silica nanoparticle cyclosporine |
| title | Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A |
| title_full | Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A |
| title_fullStr | Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A |
| title_full_unstemmed | Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A |
| title_short | Synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin A |
| title_sort | synthesis of mesoporous silica nanoparticles and drug loading of poorly water soluble drug cyclosporin a |
| topic | Silica nanoparticle cyclosporine |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2012;volume=4;issue=5;spage=92;epage=94;aulast=Lodha |
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