The role of extended synaptotagmin at membrane contact sites in cancer research
Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling. In cancer research, MCSs have been proposed to regulate tumor metabolism and fate, contr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1291506/full |
| _version_ | 1797450848023871488 |
|---|---|
| author | Yuetian Pan Yuetian Pan Dorothee Strohmer Shikai Feng Guibin Zhang Hongshang Cui Yongbin Song |
| author_facet | Yuetian Pan Yuetian Pan Dorothee Strohmer Shikai Feng Guibin Zhang Hongshang Cui Yongbin Song |
| author_sort | Yuetian Pan |
| collection | DOAJ |
| description | Membrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling. In cancer research, MCSs have been proposed to regulate tumor metabolism and fate, contributing to tumor progression, and this function could be exploited for tumor therapy. However, there is little evidence on how MCSs are involved in cancer progression. In this review, we use extended synaptotagmins (E-Syts) as an entry point to describe how MCSs affect cancer progression and may be used as new diagnostic biomarkers. We then introduced the role of E-Syt and its related pathways in calcium and lipid signaling, aiming to explain how MCSs affect tumor proliferation, progression, metastasis, apoptosis, drug resistance, and treatment through calcium and lipid signaling. Generally, this review will facilitate the understanding of the complex contact biology of cancer cells. |
| first_indexed | 2024-03-09T14:45:28Z |
| format | Article |
| id | doaj.art-7eb3a8638831480f88ef53d974cd7fe3 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-09T14:45:28Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-7eb3a8638831480f88ef53d974cd7fe32023-11-27T06:55:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-11-011110.3389/fcell.2023.12915061291506The role of extended synaptotagmin at membrane contact sites in cancer researchYuetian Pan0Yuetian Pan1Dorothee Strohmer2Shikai Feng3Guibin Zhang4Hongshang Cui5Yongbin Song6Department of General, Visceral, and Transplantation Surgery, Ludwig Maximilians University, Munich, GermanyDepartment of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of General, Visceral, and Transplantation Surgery, Ludwig Maximilians University, Munich, GermanyDepartment of General, Visceral, and Transplantation Surgery, Ludwig Maximilians University, Munich, GermanyDepartment of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Thoracic Surgery, Hebei General Hospital, Shijiazhuang, Hebei, ChinaMembrane contact sites (MCSs) are adjacent locations between the membranes of two different organelles and play important roles in various physiological processes, including cellular calcium and lipid signaling. In cancer research, MCSs have been proposed to regulate tumor metabolism and fate, contributing to tumor progression, and this function could be exploited for tumor therapy. However, there is little evidence on how MCSs are involved in cancer progression. In this review, we use extended synaptotagmins (E-Syts) as an entry point to describe how MCSs affect cancer progression and may be used as new diagnostic biomarkers. We then introduced the role of E-Syt and its related pathways in calcium and lipid signaling, aiming to explain how MCSs affect tumor proliferation, progression, metastasis, apoptosis, drug resistance, and treatment through calcium and lipid signaling. Generally, this review will facilitate the understanding of the complex contact biology of cancer cells.https://www.frontiersin.org/articles/10.3389/fcell.2023.1291506/fullmembrane contact sitescancer progressioncalcium signalinglipid signalingmetastasis |
| spellingShingle | Yuetian Pan Yuetian Pan Dorothee Strohmer Shikai Feng Guibin Zhang Hongshang Cui Yongbin Song The role of extended synaptotagmin at membrane contact sites in cancer research Frontiers in Cell and Developmental Biology membrane contact sites cancer progression calcium signaling lipid signaling metastasis |
| title | The role of extended synaptotagmin at membrane contact sites in cancer research |
| title_full | The role of extended synaptotagmin at membrane contact sites in cancer research |
| title_fullStr | The role of extended synaptotagmin at membrane contact sites in cancer research |
| title_full_unstemmed | The role of extended synaptotagmin at membrane contact sites in cancer research |
| title_short | The role of extended synaptotagmin at membrane contact sites in cancer research |
| title_sort | role of extended synaptotagmin at membrane contact sites in cancer research |
| topic | membrane contact sites cancer progression calcium signaling lipid signaling metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1291506/full |
| work_keys_str_mv | AT yuetianpan theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT yuetianpan theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT dorotheestrohmer theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT shikaifeng theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT guibinzhang theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT hongshangcui theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT yongbinsong theroleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT yuetianpan roleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT yuetianpan roleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT dorotheestrohmer roleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT shikaifeng roleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT guibinzhang roleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT hongshangcui roleofextendedsynaptotagminatmembranecontactsitesincancerresearch AT yongbinsong roleofextendedsynaptotagminatmembranecontactsitesincancerresearch |