Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study
The excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic–ischemic brain damage (HIBD). In the present study, changes in glutamate metabolism in the basal ganglia were detected by proton magnetic resonance spectroscopy (1H-MRS...
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00237/full |
| _version_ | 1818429461909995520 |
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| author | Xiao-ming Wang Yu-xue Dang Kai-ning Shi |
| author_facet | Xiao-ming Wang Yu-xue Dang Kai-ning Shi |
| author_sort | Xiao-ming Wang |
| collection | DOAJ |
| description | The excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic–ischemic brain damage (HIBD). In the present study, changes in glutamate metabolism in the basal ganglia were detected by proton magnetic resonance spectroscopy (1H-MRS) at 0–6, 8–12, 24–30, and 48–60 h after the induction of hypoxia-ischemia (HI) in newborn piglets. Meanwhile, correlation analysis was performed by combining the microcirculatory perfusion informations acquired by intravoxel incoherent motion (IVIM) scan to explore their possible interaction mechanism. The results suggested that Glu level in the basal ganglia underwent a “two-phase” change after HI; perfusion fraction f, an IVIM-derived perfusion parameter, was clearly decreased in the early stage after HI, then demonstrated a transient and slight recovery process, and thereafter continued to decrease. The changes in f and Glu level were in a significant negative correlation (r = −0.643, P = 0.001). Our study results revealed that Glu level is closely associated with the microcirculatory perfusion changes in the acute stage of HIBD. |
| first_indexed | 2024-12-14T15:17:54Z |
| format | Article |
| id | doaj.art-7eb448575a194a92915a09840bc44a5a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T15:17:54Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-7eb448575a194a92915a09840bc44a5a2022-12-21T22:56:15ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-04-01810.3389/fphys.2017.00237257498Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR StudyXiao-ming Wang0Yu-xue Dang1Kai-ning Shi2Department of Radiology, Shengjing Hospital of China Medical UniversityShenyang, ChinaDepartment of Radiology, Shengjing Hospital of China Medical UniversityShenyang, ChinaDepartment of Imaging Systems Clinical Science, Philips HealthcareBeijing, ChinaThe excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic–ischemic brain damage (HIBD). In the present study, changes in glutamate metabolism in the basal ganglia were detected by proton magnetic resonance spectroscopy (1H-MRS) at 0–6, 8–12, 24–30, and 48–60 h after the induction of hypoxia-ischemia (HI) in newborn piglets. Meanwhile, correlation analysis was performed by combining the microcirculatory perfusion informations acquired by intravoxel incoherent motion (IVIM) scan to explore their possible interaction mechanism. The results suggested that Glu level in the basal ganglia underwent a “two-phase” change after HI; perfusion fraction f, an IVIM-derived perfusion parameter, was clearly decreased in the early stage after HI, then demonstrated a transient and slight recovery process, and thereafter continued to decrease. The changes in f and Glu level were in a significant negative correlation (r = −0.643, P = 0.001). Our study results revealed that Glu level is closely associated with the microcirculatory perfusion changes in the acute stage of HIBD.http://journal.frontiersin.org/article/10.3389/fphys.2017.00237/fullhypoxic–ischemic brain damage1H-MRSIVIMglutamateperfusion |
| spellingShingle | Xiao-ming Wang Yu-xue Dang Kai-ning Shi Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study Frontiers in Physiology hypoxic–ischemic brain damage 1H-MRS IVIM glutamate perfusion |
| title | Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study |
| title_full | Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study |
| title_fullStr | Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study |
| title_full_unstemmed | Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study |
| title_short | Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study |
| title_sort | early changes in glutamate metabolism and perfusion in basal ganglia following hypoxia ischemia in neonatal piglets a multi sequence 3 0t mr study |
| topic | hypoxic–ischemic brain damage 1H-MRS IVIM glutamate perfusion |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00237/full |
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