Wnt Signaling Pathway Is among the Drivers of Liver Metastasis
Liver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. Its role in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Livers |
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| Online Access: | https://www.mdpi.com/2673-4389/1/4/15 |
| _version_ | 1797502921572614144 |
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| author | Ivana Samaržija |
| author_facet | Ivana Samaržija |
| author_sort | Ivana Samaržija |
| collection | DOAJ |
| description | Liver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. Its role in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, metastasis formation, and other steps of the metastatic cascade are presented. Additionally, the roles of the Wnt signaling pathway in the liver metastasis formation of colorectal, breast, gastric, lung, melanoma, pancreatic, and prostate cancer are explored. The special emphasis is given to the role of the Wnt signaling pathway in the communication between the many of the components of the primary and secondary cancer microenvironment that contribute to the metastatic outgrowth in the liver. The data presented herein are a review of the most recent publications and advances in the field that add to the idea that the Wnt pathway is among the drivers of liver metastasis and that its targeting could potentially relieve liver metastasis–related complications. |
| first_indexed | 2024-03-10T03:43:04Z |
| format | Article |
| id | doaj.art-7eb8e50093c9426f9cc4271110edbb20 |
| institution | Directory Open Access Journal |
| issn | 2673-4389 |
| language | English |
| last_indexed | 2024-03-10T03:43:04Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Livers |
| spelling | doaj.art-7eb8e50093c9426f9cc4271110edbb202023-11-23T09:15:33ZengMDPI AGLivers2673-43892021-10-011418020010.3390/livers1040015Wnt Signaling Pathway Is among the Drivers of Liver MetastasisIvana Samaržija0Laboratory for Epigenomics, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, CroatiaLiver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. Its role in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, metastasis formation, and other steps of the metastatic cascade are presented. Additionally, the roles of the Wnt signaling pathway in the liver metastasis formation of colorectal, breast, gastric, lung, melanoma, pancreatic, and prostate cancer are explored. The special emphasis is given to the role of the Wnt signaling pathway in the communication between the many of the components of the primary and secondary cancer microenvironment that contribute to the metastatic outgrowth in the liver. The data presented herein are a review of the most recent publications and advances in the field that add to the idea that the Wnt pathway is among the drivers of liver metastasis and that its targeting could potentially relieve liver metastasis–related complications.https://www.mdpi.com/2673-4389/1/4/15Wnt signaling pathwayliver metastasishepatocellular carcinomacolorectal cancerbreast cancergastric cancer |
| spellingShingle | Ivana Samaržija Wnt Signaling Pathway Is among the Drivers of Liver Metastasis Livers Wnt signaling pathway liver metastasis hepatocellular carcinoma colorectal cancer breast cancer gastric cancer |
| title | Wnt Signaling Pathway Is among the Drivers of Liver Metastasis |
| title_full | Wnt Signaling Pathway Is among the Drivers of Liver Metastasis |
| title_fullStr | Wnt Signaling Pathway Is among the Drivers of Liver Metastasis |
| title_full_unstemmed | Wnt Signaling Pathway Is among the Drivers of Liver Metastasis |
| title_short | Wnt Signaling Pathway Is among the Drivers of Liver Metastasis |
| title_sort | wnt signaling pathway is among the drivers of liver metastasis |
| topic | Wnt signaling pathway liver metastasis hepatocellular carcinoma colorectal cancer breast cancer gastric cancer |
| url | https://www.mdpi.com/2673-4389/1/4/15 |
| work_keys_str_mv | AT ivanasamarzija wntsignalingpathwayisamongthedriversoflivermetastasis |