Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex
Abstract Background Numerous studies in the past have expanded our understanding of the genetic differences of global distributed cyanobacteria that originated around billions of years ago, however, unraveling how gene gain and loss drive the genetic evolution of cyanobacterial species, and the trad...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12864-023-09555-3 |
| _version_ | 1797577959600553984 |
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| author | Xian Zhang Lijun Xiao Jiahui Liu Qibai Tian Jiaqi Xie |
| author_facet | Xian Zhang Lijun Xiao Jiahui Liu Qibai Tian Jiaqi Xie |
| author_sort | Xian Zhang |
| collection | DOAJ |
| description | Abstract Background Numerous studies in the past have expanded our understanding of the genetic differences of global distributed cyanobacteria that originated around billions of years ago, however, unraveling how gene gain and loss drive the genetic evolution of cyanobacterial species, and the trade-off of these evolutionary forces are still the central but poorly understood issues. Results To delineate the contribution of gene flow in mediating the hereditary differentiation and shaping the microbial evolution, a global genome-wide study of bloom-forming cyanobacterium, Microcystis aeruginosa species complex, provided robust evidence for genetic diversity, reflected by enormous variation in gene repertoire among various strains. Mathematical extrapolation showed an ‘open’ microbial pan-genome of M. aeruginosa species, since novel genes were predicted to be introduced after new genomes were sequenced. Identification of numerous horizontal gene transfer’s signatures in genome regions of interest suggested that genome expansion via transformation and phage-mediated transduction across bacterial lineage as an evolutionary route may contribute to the differentiation of Microcystis functions (e.g., carbohydrate metabolism, amino acid metabolism, and energy metabolism). Meanwhile, the selective loss of some dispensable genes at the cost of metabolic versatility is as a mean of adaptive evolution that has the potential to increase the biological fitness. Conclusions Now that the recruitment of novel genes was accompanied by a parallel loss of some other ones, a trade-off in gene content may drive the divergent differentiation of M. aeruginosa genomes. Our study provides a genetic framework for the evolution of M. aeruginosa species and illustrates their possible evolutionary patterns. |
| first_indexed | 2024-03-10T22:15:28Z |
| format | Article |
| id | doaj.art-7eb8e6cf4d344aaebb50a733b219c6b0 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-03-10T22:15:28Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-7eb8e6cf4d344aaebb50a733b219c6b02023-11-19T12:27:15ZengBMCBMC Genomics1471-21642023-08-0124111610.1186/s12864-023-09555-3Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complexXian Zhang0Lijun Xiao1Jiahui Liu2Qibai Tian3Jiaqi Xie4Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South UniversityGuangdong Corps Hospital of Chinese People’s Armed Police ForcesDepartment of Occupational and Environmental Health, Xiangya School of Public Health, Central South UniversityDepartment of Occupational and Environmental Health, Xiangya School of Public Health, Central South UniversityHunan Food and Drug Vocational CollegeAbstract Background Numerous studies in the past have expanded our understanding of the genetic differences of global distributed cyanobacteria that originated around billions of years ago, however, unraveling how gene gain and loss drive the genetic evolution of cyanobacterial species, and the trade-off of these evolutionary forces are still the central but poorly understood issues. Results To delineate the contribution of gene flow in mediating the hereditary differentiation and shaping the microbial evolution, a global genome-wide study of bloom-forming cyanobacterium, Microcystis aeruginosa species complex, provided robust evidence for genetic diversity, reflected by enormous variation in gene repertoire among various strains. Mathematical extrapolation showed an ‘open’ microbial pan-genome of M. aeruginosa species, since novel genes were predicted to be introduced after new genomes were sequenced. Identification of numerous horizontal gene transfer’s signatures in genome regions of interest suggested that genome expansion via transformation and phage-mediated transduction across bacterial lineage as an evolutionary route may contribute to the differentiation of Microcystis functions (e.g., carbohydrate metabolism, amino acid metabolism, and energy metabolism). Meanwhile, the selective loss of some dispensable genes at the cost of metabolic versatility is as a mean of adaptive evolution that has the potential to increase the biological fitness. Conclusions Now that the recruitment of novel genes was accompanied by a parallel loss of some other ones, a trade-off in gene content may drive the divergent differentiation of M. aeruginosa genomes. Our study provides a genetic framework for the evolution of M. aeruginosa species and illustrates their possible evolutionary patterns.https://doi.org/10.1186/s12864-023-09555-3Microcystis aeruginosaGene flowHereditary differentiationAdaptive evolutionTrade-off |
| spellingShingle | Xian Zhang Lijun Xiao Jiahui Liu Qibai Tian Jiaqi Xie Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex BMC Genomics Microcystis aeruginosa Gene flow Hereditary differentiation Adaptive evolution Trade-off |
| title | Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex |
| title_full | Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex |
| title_fullStr | Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex |
| title_full_unstemmed | Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex |
| title_short | Trade-off in genome turnover events leading to adaptive evolution of Microcystis aeruginosa species complex |
| title_sort | trade off in genome turnover events leading to adaptive evolution of microcystis aeruginosa species complex |
| topic | Microcystis aeruginosa Gene flow Hereditary differentiation Adaptive evolution Trade-off |
| url | https://doi.org/10.1186/s12864-023-09555-3 |
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