Role of Microbiota in Pathogenesis and Management of Viral Hepatitis
Hepatitis is a condition that can be self-limiting or can progress to fibrosis (scarring), cirrhosis, or liver cancer. These days, gut microbiota becomes an important part of our immune system, which is important for disease progression or recovery. Translocation of gut microbial and metabolic produ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.00341/full |
| _version_ | 1818107970406318080 |
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| author | Rashi Sehgal Onkar Bedi Nirupma Trehanpati |
| author_facet | Rashi Sehgal Onkar Bedi Nirupma Trehanpati |
| author_sort | Rashi Sehgal |
| collection | DOAJ |
| description | Hepatitis is a condition that can be self-limiting or can progress to fibrosis (scarring), cirrhosis, or liver cancer. These days, gut microbiota becomes an important part of our immune system, which is important for disease progression or recovery. Translocation of gut microbial and metabolic products causes intestinal inflammation by modulating immune cells leading to impairment of the primary barrier. But there are limited studies discussing pathogenesis and management of hepatitis with gut microbiota. In this review, we have discussed the role of gut microbiota in pathogenesis and management of various hepatitis, especially hepatitis B and C. We have discussed the role of bacterial products, LPS-TLR4 pathway, and unmethylated CpG DNA, which ultimately affects downstream NF-kB signaling in hepatitis. Finally, we have discussed the role of fecal microbiota transplantation in the management of hepatitis. |
| first_indexed | 2024-12-11T02:07:55Z |
| format | Article |
| id | doaj.art-7eb91aa4b14b4c72a3fc5d96024a9399 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T02:07:55Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-7eb91aa4b14b4c72a3fc5d96024a93992022-12-22T01:24:20ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-08-011010.3389/fcimb.2020.00341542396Role of Microbiota in Pathogenesis and Management of Viral HepatitisRashi SehgalOnkar BediNirupma TrehanpatiHepatitis is a condition that can be self-limiting or can progress to fibrosis (scarring), cirrhosis, or liver cancer. These days, gut microbiota becomes an important part of our immune system, which is important for disease progression or recovery. Translocation of gut microbial and metabolic products causes intestinal inflammation by modulating immune cells leading to impairment of the primary barrier. But there are limited studies discussing pathogenesis and management of hepatitis with gut microbiota. In this review, we have discussed the role of gut microbiota in pathogenesis and management of various hepatitis, especially hepatitis B and C. We have discussed the role of bacterial products, LPS-TLR4 pathway, and unmethylated CpG DNA, which ultimately affects downstream NF-kB signaling in hepatitis. Finally, we have discussed the role of fecal microbiota transplantation in the management of hepatitis.https://www.frontiersin.org/article/10.3389/fcimb.2020.00341/fullhepatitisfecal microbiota transplantationgut microbiotalipopolysaccharides (LPS)probioticbacteria |
| spellingShingle | Rashi Sehgal Onkar Bedi Nirupma Trehanpati Role of Microbiota in Pathogenesis and Management of Viral Hepatitis Frontiers in Cellular and Infection Microbiology hepatitis fecal microbiota transplantation gut microbiota lipopolysaccharides (LPS) probiotic bacteria |
| title | Role of Microbiota in Pathogenesis and Management of Viral Hepatitis |
| title_full | Role of Microbiota in Pathogenesis and Management of Viral Hepatitis |
| title_fullStr | Role of Microbiota in Pathogenesis and Management of Viral Hepatitis |
| title_full_unstemmed | Role of Microbiota in Pathogenesis and Management of Viral Hepatitis |
| title_short | Role of Microbiota in Pathogenesis and Management of Viral Hepatitis |
| title_sort | role of microbiota in pathogenesis and management of viral hepatitis |
| topic | hepatitis fecal microbiota transplantation gut microbiota lipopolysaccharides (LPS) probiotic bacteria |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.00341/full |
| work_keys_str_mv | AT rashisehgal roleofmicrobiotainpathogenesisandmanagementofviralhepatitis AT onkarbedi roleofmicrobiotainpathogenesisandmanagementofviralhepatitis AT nirupmatrehanpati roleofmicrobiotainpathogenesisandmanagementofviralhepatitis |