Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers
The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). For the treatment of diabetic foot ulcers, negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) was also investigated. There were 653 patients i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1051299/full |
| _version_ | 1797980680879079424 |
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| author | Yanling Wang Bang Liu Yinzhen Pi Li Hu Yeling Yuan Jiao Luo Yixiao Tao Ping Li Shan Lu Wei Song |
| author_facet | Yanling Wang Bang Liu Yinzhen Pi Li Hu Yeling Yuan Jiao Luo Yixiao Tao Ping Li Shan Lu Wei Song |
| author_sort | Yanling Wang |
| collection | DOAJ |
| description | The purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). For the treatment of diabetic foot ulcers, negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) was also investigated. There were 653 patients in the diabetic foot ulcer group and 510 patients in the diabetic patients without foot ulceration (NFU) group, for a total of 1163 patients in the study samples after individuals without follow-up were excluded. The patients were randomized into two groups: the negative pressure wound therapy group and the negative pressure wound therapy combined with the PRP group. The findings of the univariate analysis revealed the blood indicators for predicting diabetic foot ulcer morbidity risk factors, such as C-reactive protein, albumin, creatinine, alkaline phosphatase, procalcitonin, platelets, 25-hydroxyvitamin D, β-2-microglobulin, monocyte ratio, low-density protein cholesterol (LDL), triglyceride, alanine aminotransferase (ALT), aminotransferase (AST), creatine kinase (CK) and total cholesterol. Using logistic regression analysis revealed only albumin and age to be independent predictors of diabetic foot ulcer mortality. Our study also revealed that, compared to negative pressure wound therapy alone, negative pressure wound therapy combined with PRP accelerated wound healing and reduced the mortality rate. According to the findings of this pilot study, new risk factors for diabetic foot ulcer morbidity and mortality have been found, and negative pressure wound therapy combined with PRP therapy may provide the first information that it is an effective adjunct treatment for diabetic foot ulcers. |
| first_indexed | 2024-04-11T05:57:35Z |
| format | Article |
| id | doaj.art-7ebb99d2eb254eaa9376958bcd0cdf13 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T05:57:35Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7ebb99d2eb254eaa9376958bcd0cdf132022-12-22T04:41:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-12-011310.3389/fphar.2022.10512991051299Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcersYanling Wang0Bang Liu1Yinzhen Pi2Li Hu3Yeling Yuan4Jiao Luo5Yixiao Tao6Ping Li7Shan Lu8Wei Song9Changsha Maternal and Child Health Hospital Affiliated to Hunan Normal University, Changsha, ChinaChangsha Maternal and Child Health Hospital Affiliated to Hunan Normal University, Changsha, ChinaThe First Hospital of Changsha, Changsha, ChinaThe First Hospital of Changsha, Changsha, ChinaDepartment of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaChangsha Maternal and Child Health Hospital Affiliated to Hunan Normal University, Changsha, ChinaChangsha Maternal and Child Health Hospital Affiliated to Hunan Normal University, Changsha, ChinaChangsha Maternal and Child Health Hospital Affiliated to Hunan Normal University, Changsha, ChinaChangsha Maternal and Child Health Hospital Affiliated to Hunan Normal University, Changsha, ChinaNational & Local Joint Engineering Research Center of High-Throughput Drug Screening Technology, College of Health Science and Engineering, Hubei University, Wuhan, ChinaThe purpose of this study was to assess the risk factors for morbidity and mortality of diabetic foot ulcers (DFUs). For the treatment of diabetic foot ulcers, negative pressure wound therapy (NPWT) combined with platelet-rich plasma-fibrin glue (PRP) was also investigated. There were 653 patients in the diabetic foot ulcer group and 510 patients in the diabetic patients without foot ulceration (NFU) group, for a total of 1163 patients in the study samples after individuals without follow-up were excluded. The patients were randomized into two groups: the negative pressure wound therapy group and the negative pressure wound therapy combined with the PRP group. The findings of the univariate analysis revealed the blood indicators for predicting diabetic foot ulcer morbidity risk factors, such as C-reactive protein, albumin, creatinine, alkaline phosphatase, procalcitonin, platelets, 25-hydroxyvitamin D, β-2-microglobulin, monocyte ratio, low-density protein cholesterol (LDL), triglyceride, alanine aminotransferase (ALT), aminotransferase (AST), creatine kinase (CK) and total cholesterol. Using logistic regression analysis revealed only albumin and age to be independent predictors of diabetic foot ulcer mortality. Our study also revealed that, compared to negative pressure wound therapy alone, negative pressure wound therapy combined with PRP accelerated wound healing and reduced the mortality rate. According to the findings of this pilot study, new risk factors for diabetic foot ulcer morbidity and mortality have been found, and negative pressure wound therapy combined with PRP therapy may provide the first information that it is an effective adjunct treatment for diabetic foot ulcers.https://www.frontiersin.org/articles/10.3389/fphar.2022.1051299/fulldiabetic foot ulcers (DFUs)diabetic patients without foot ulceration (NFU)negative pressure wound therapy (NPWT)platelet-rich plasma-fibrin glue (PRP)mortality |
| spellingShingle | Yanling Wang Bang Liu Yinzhen Pi Li Hu Yeling Yuan Jiao Luo Yixiao Tao Ping Li Shan Lu Wei Song Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers Frontiers in Pharmacology diabetic foot ulcers (DFUs) diabetic patients without foot ulceration (NFU) negative pressure wound therapy (NPWT) platelet-rich plasma-fibrin glue (PRP) mortality |
| title | Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers |
| title_full | Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers |
| title_fullStr | Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers |
| title_full_unstemmed | Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers |
| title_short | Risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet-rich plasma therapy in the treatment of diabetic foot ulcers |
| title_sort | risk factors for diabetic foot ulcers mortality and novel negative pressure combined with platelet rich plasma therapy in the treatment of diabetic foot ulcers |
| topic | diabetic foot ulcers (DFUs) diabetic patients without foot ulceration (NFU) negative pressure wound therapy (NPWT) platelet-rich plasma-fibrin glue (PRP) mortality |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1051299/full |
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