Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy
Background: To compare the efficacy and safety of iodized oil versus polyvinyl alcohol (PVA) particles in portal vein embolization (PVE) before partial hepatectomy. Methods: From October 2016 to December 2021, 86 patients who planned to undergo hepatectomy after PVE were enrolled, including 61 patie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958423016524 |
| _version_ | 1797328856629116928 |
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| author | Boyang Wu Xin Huang Zhizhong Ren Ying Liu Xiaowei Yang Yaqin Wang Qian Chen Jiahong Dong Canhong Xiang Yuewei Zhang |
| author_facet | Boyang Wu Xin Huang Zhizhong Ren Ying Liu Xiaowei Yang Yaqin Wang Qian Chen Jiahong Dong Canhong Xiang Yuewei Zhang |
| author_sort | Boyang Wu |
| collection | DOAJ |
| description | Background: To compare the efficacy and safety of iodized oil versus polyvinyl alcohol (PVA) particles in portal vein embolization (PVE) before partial hepatectomy. Methods: From October 2016 to December 2021, 86 patients who planned to undergo hepatectomy after PVE were enrolled, including 61 patients post-PVE with PVA particles + coils and 25 patients post-PVE with iodized oil + coils. All patients underwent CT examination before and 2–3 weeks after PVE to evaluate the future liver remnant (FLR). The intercohort comparison included the degree of liver volume growth, changes in laboratory data, and adverse events. Results: There was no significant difference in the resection rate between the iodized oil group and the PVA particle group (68 % vs. 70 %, p = 0.822). In terms of the degree of hypertrophy (9.52 % ± 13.47 vs. 4.03 % ± 10.55, p = 0.047) and kinetic growth rate (4.07 % ± 5.4 vs. 1.55 % ± 4.63, p = 0.032), the iodized oil group was superior to the PVA group. The PVE operation time in the PVA particle group was shorter than that in the iodized oil group (121. 72 min ± 34.45 vs. 156. 2 min ± 71.58, p = 0.029). There was no significant difference in the degree of hypertrophy between the high bilirubin group and the control group (5.32 % ± 9.21 vs. 6.1 % ± 14.79, p = 0.764). Only 1 patient had a major complication. Conclusions: Compared with PVA particles, iodized oil PVE can significantly increase liver volume and the degree of hypertrophy without any significant difference in safety. |
| first_indexed | 2024-03-08T06:56:58Z |
| format | Article |
| id | doaj.art-7ebc7fadb26843a09bdbd1c53e87f9c3 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-03-08T06:56:58Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-7ebc7fadb26843a09bdbd1c53e87f9c32024-02-03T06:34:42ZengElsevierAsian Journal of Surgery1015-95842024-02-01472874879Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomyBoyang Wu0Xin Huang1Zhizhong Ren2Ying Liu3Xiaowei Yang4Yaqin Wang5Qian Chen6Jiahong Dong7Canhong Xiang8Yuewei Zhang9Hepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China; School of Medicine, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, ChinaThorgene Co., Ltd., Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China; Key Laboratory of Digital Intelligence Hepatology (Ministry of Education), School of Clinical Medicine, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, ChinaHepatobiliary Pancreatic Center Department, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China; Corresponding author. Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua University, Litang Street 168, Beijing, 102218, China.Background: To compare the efficacy and safety of iodized oil versus polyvinyl alcohol (PVA) particles in portal vein embolization (PVE) before partial hepatectomy. Methods: From October 2016 to December 2021, 86 patients who planned to undergo hepatectomy after PVE were enrolled, including 61 patients post-PVE with PVA particles + coils and 25 patients post-PVE with iodized oil + coils. All patients underwent CT examination before and 2–3 weeks after PVE to evaluate the future liver remnant (FLR). The intercohort comparison included the degree of liver volume growth, changes in laboratory data, and adverse events. Results: There was no significant difference in the resection rate between the iodized oil group and the PVA particle group (68 % vs. 70 %, p = 0.822). In terms of the degree of hypertrophy (9.52 % ± 13.47 vs. 4.03 % ± 10.55, p = 0.047) and kinetic growth rate (4.07 % ± 5.4 vs. 1.55 % ± 4.63, p = 0.032), the iodized oil group was superior to the PVA group. The PVE operation time in the PVA particle group was shorter than that in the iodized oil group (121. 72 min ± 34.45 vs. 156. 2 min ± 71.58, p = 0.029). There was no significant difference in the degree of hypertrophy between the high bilirubin group and the control group (5.32 % ± 9.21 vs. 6.1 % ± 14.79, p = 0.764). Only 1 patient had a major complication. Conclusions: Compared with PVA particles, iodized oil PVE can significantly increase liver volume and the degree of hypertrophy without any significant difference in safety.http://www.sciencedirect.com/science/article/pii/S1015958423016524Portal vein embolizationFuture liver remnantHyperbilirubinemiaPVA particlesIodized oil |
| spellingShingle | Boyang Wu Xin Huang Zhizhong Ren Ying Liu Xiaowei Yang Yaqin Wang Qian Chen Jiahong Dong Canhong Xiang Yuewei Zhang Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy Asian Journal of Surgery Portal vein embolization Future liver remnant Hyperbilirubinemia PVA particles Iodized oil |
| title | Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy |
| title_full | Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy |
| title_fullStr | Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy |
| title_full_unstemmed | Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy |
| title_short | Comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy |
| title_sort | comparing iodized oil with polyvinyl alcohol for portal vein embolization in promoting liver remnant increase before partial hepatectomy |
| topic | Portal vein embolization Future liver remnant Hyperbilirubinemia PVA particles Iodized oil |
| url | http://www.sciencedirect.com/science/article/pii/S1015958423016524 |
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