Sepsis and the muscle tissue. A narrative review
Sepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity rates and ICU length of stay. The underlying pathophysiology is complex, involving mitochondrial dysfunction, increased protein breakdown and m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-09-01
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| Series: | Romanian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/rjim-2021-0005 |
| _version_ | 1828399240609529856 |
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| author | Oikonomou Eleousa Paraskevas Themistoklis Velissaris Dimitris |
| author_facet | Oikonomou Eleousa Paraskevas Themistoklis Velissaris Dimitris |
| author_sort | Oikonomou Eleousa |
| collection | DOAJ |
| description | Sepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity rates and ICU length of stay. The underlying pathophysiology is complex, involving mitochondrial dysfunction, increased protein breakdown and muscle inexcitability. Sepsis induced myopathy is characterized by several electrophysiological and histopathological abnormalities of the muscle, also has clinical consequences such as flaccid weakness and failure to wean from ventilator. In order to reach definite diagnosis, clinical assessment, electrophysiological studies and muscle biopsy must be performed, which can be challenging in daily practice. Ultrasonography as a screening tool can be a promising alternative, especially in the ICU setting. Sepsis and mechanical ventilation have additive effects leading to diaphragm dysfunction thus complicating the patient’s clinical course and recovery. Here, we summarize the effects of the septic syndrome on the muscle tissue based on the existing literature. |
| first_indexed | 2024-12-10T09:14:34Z |
| format | Article |
| id | doaj.art-7ebd7a74840b4832a883468e7c17fd91 |
| institution | Directory Open Access Journal |
| issn | 2501-062X |
| language | English |
| last_indexed | 2024-12-10T09:14:34Z |
| publishDate | 2021-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Internal Medicine |
| spelling | doaj.art-7ebd7a74840b4832a883468e7c17fd912022-12-22T01:54:54ZengSciendoRomanian Journal of Internal Medicine2501-062X2021-09-0159321822610.2478/rjim-2021-0005Sepsis and the muscle tissue. A narrative reviewOikonomou Eleousa0Paraskevas Themistoklis1Velissaris Dimitris2Department of Internal Medicine, University Hospital of Patras, GreeceDepartment of Internal Medicine, University Hospital of Patras, GreeceDepartment of Internal Medicine, University Hospital of Patras, GreeceSepsis and septic shock are considered major factors in the development of myopathy in critically ill patients, which is correlated with increased morbidity rates and ICU length of stay. The underlying pathophysiology is complex, involving mitochondrial dysfunction, increased protein breakdown and muscle inexcitability. Sepsis induced myopathy is characterized by several electrophysiological and histopathological abnormalities of the muscle, also has clinical consequences such as flaccid weakness and failure to wean from ventilator. In order to reach definite diagnosis, clinical assessment, electrophysiological studies and muscle biopsy must be performed, which can be challenging in daily practice. Ultrasonography as a screening tool can be a promising alternative, especially in the ICU setting. Sepsis and mechanical ventilation have additive effects leading to diaphragm dysfunction thus complicating the patient’s clinical course and recovery. Here, we summarize the effects of the septic syndrome on the muscle tissue based on the existing literature.https://doi.org/10.2478/rjim-2021-0005sepsismuscle tissuemyopathyintensive care unitdiaphragmcritical illness |
| spellingShingle | Oikonomou Eleousa Paraskevas Themistoklis Velissaris Dimitris Sepsis and the muscle tissue. A narrative review Romanian Journal of Internal Medicine sepsis muscle tissue myopathy intensive care unit diaphragm critical illness |
| title | Sepsis and the muscle tissue. A narrative review |
| title_full | Sepsis and the muscle tissue. A narrative review |
| title_fullStr | Sepsis and the muscle tissue. A narrative review |
| title_full_unstemmed | Sepsis and the muscle tissue. A narrative review |
| title_short | Sepsis and the muscle tissue. A narrative review |
| title_sort | sepsis and the muscle tissue a narrative review |
| topic | sepsis muscle tissue myopathy intensive care unit diaphragm critical illness |
| url | https://doi.org/10.2478/rjim-2021-0005 |
| work_keys_str_mv | AT oikonomoueleousa sepsisandthemuscletissueanarrativereview AT paraskevasthemistoklis sepsisandthemuscletissueanarrativereview AT velissarisdimitris sepsisandthemuscletissueanarrativereview |