Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial
<p><strong>Introduction:</strong> Considering the existing contradictions regarding effectiveness of intravenous (IV) lidocaine, especially in emergency department (ED), the present study was designed to compare the analgesic effect of IV lidocaine and morphine sulfate in pain mana...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2017-01-01
|
| Series: | Emergency |
| Subjects: | |
| Online Access: | http://journals.sbmu.ac.ir/emergency/article/view/17269 |
| _version_ | 1818454969851838464 |
|---|---|
| author | Arash Forouzan Hassan Barzegari Hassan Motamed Ali Khavanin Hamideh Shiri |
| author_facet | Arash Forouzan Hassan Barzegari Hassan Motamed Ali Khavanin Hamideh Shiri |
| author_sort | Arash Forouzan |
| collection | DOAJ |
| description | <p><strong>Introduction:</strong> Considering the existing contradictions regarding effectiveness of intravenous (IV) lidocaine, especially in emergency department (ED), the present study was designed to compare the analgesic effect of IV lidocaine and morphine sulfate in pain management for extremity bone fractures. <strong>Method:</strong> In this triple blind clinical trial, 15 to 65 year-old patients with extremity fractures and in need of pain management were randomly allocated to either IV lidocaine or morphine sulfate group and were compared regarding severity of pain 5, 10, 15, 20, 25, and 30 minutes after infusion via intention to treat analysis. The absolute risk reduction, number needed to treat and relative risk of IV lidocaine after 30 minutes were 0.40 (95%CI: 0.25 – 0.64), 7 (95%CI: 3.7 – 23.1), and 20.71 (95%CI: 10.91 – 30.51), respectively. <strong>Results: </strong>280 patients with the mean age of 32.50 ± 12.77 years were randomly divided into 2 equal groups of 140 (73.9% male). The 2 groups had similar baseline characteristics. 15 minutes after injection success rate was 49.28% in lidocaine and 33.57% in morphine sulfate group (p = 0.011), and after 30 minutes it reached 85.71% and 65.00%, respectively (p < 0.001). <strong>Conclusion: </strong>Based on the results of the present study, IV lidocaine could be considered as a reasonable alternative choice for pain management in ED. </p> |
| first_indexed | 2024-12-14T22:03:20Z |
| format | Article |
| id | doaj.art-7ec0990142084c8ebf4b4f815112f42b |
| institution | Directory Open Access Journal |
| issn | 2345-4563 2345-4571 |
| language | English |
| last_indexed | 2024-12-14T22:03:20Z |
| publishDate | 2017-01-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Emergency |
| spelling | doaj.art-7ec0990142084c8ebf4b4f815112f42b2022-12-21T22:45:55ZengShahid Beheshti University of Medical SciencesEmergency2345-45632345-45712017-01-0151e68e6810.22037/emergency.v5i1.172698913Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical TrialArash Forouzan0Hassan Barzegari1Hassan Motamed2Ali Khavanin3Hamideh Shiri4Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.<p><strong>Introduction:</strong> Considering the existing contradictions regarding effectiveness of intravenous (IV) lidocaine, especially in emergency department (ED), the present study was designed to compare the analgesic effect of IV lidocaine and morphine sulfate in pain management for extremity bone fractures. <strong>Method:</strong> In this triple blind clinical trial, 15 to 65 year-old patients with extremity fractures and in need of pain management were randomly allocated to either IV lidocaine or morphine sulfate group and were compared regarding severity of pain 5, 10, 15, 20, 25, and 30 minutes after infusion via intention to treat analysis. The absolute risk reduction, number needed to treat and relative risk of IV lidocaine after 30 minutes were 0.40 (95%CI: 0.25 – 0.64), 7 (95%CI: 3.7 – 23.1), and 20.71 (95%CI: 10.91 – 30.51), respectively. <strong>Results: </strong>280 patients with the mean age of 32.50 ± 12.77 years were randomly divided into 2 equal groups of 140 (73.9% male). The 2 groups had similar baseline characteristics. 15 minutes after injection success rate was 49.28% in lidocaine and 33.57% in morphine sulfate group (p = 0.011), and after 30 minutes it reached 85.71% and 65.00%, respectively (p < 0.001). <strong>Conclusion: </strong>Based on the results of the present study, IV lidocaine could be considered as a reasonable alternative choice for pain management in ED. </p>http://journals.sbmu.ac.ir/emergency/article/view/17269Lidocainemorphinepain managementemergency service, hospitalfractures, bone |
| spellingShingle | Arash Forouzan Hassan Barzegari Hassan Motamed Ali Khavanin Hamideh Shiri Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial Emergency Lidocaine morphine pain management emergency service, hospital fractures, bone |
| title | Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial |
| title_full | Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial |
| title_fullStr | Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial |
| title_full_unstemmed | Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial |
| title_short | Intravenous Lidocaine versus Morphine Sulfate in Pain Management for Extremity Fractures; a Clinical Trial |
| title_sort | intravenous lidocaine versus morphine sulfate in pain management for extremity fractures a clinical trial |
| topic | Lidocaine morphine pain management emergency service, hospital fractures, bone |
| url | http://journals.sbmu.ac.ir/emergency/article/view/17269 |
| work_keys_str_mv | AT arashforouzan intravenouslidocaineversusmorphinesulfateinpainmanagementforextremityfracturesaclinicaltrial AT hassanbarzegari intravenouslidocaineversusmorphinesulfateinpainmanagementforextremityfracturesaclinicaltrial AT hassanmotamed intravenouslidocaineversusmorphinesulfateinpainmanagementforextremityfracturesaclinicaltrial AT alikhavanin intravenouslidocaineversusmorphinesulfateinpainmanagementforextremityfracturesaclinicaltrial AT hamidehshiri intravenouslidocaineversusmorphinesulfateinpainmanagementforextremityfracturesaclinicaltrial |