Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports
Introduction A septum pellucidum cyst is defined as a fluid collection between the lateral ventricles whose walls have a lateral curvature and are separated by 10 mm or more . Most of these cysts are benign and their clinical significance should be considered as a neurodevelopmental anomaly that ma...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823019533/type/journal_article |
| _version_ | 1797616071908261888 |
|---|---|
| author | M. Belak |
| author_facet | M. Belak |
| author_sort | M. Belak |
| collection | DOAJ |
| description |
Introduction
A septum pellucidum cyst is defined as a fluid collection between the lateral ventricles whose walls have a lateral curvature and are separated by 10 mm or more . Most of these cysts are benign and their clinical significance should be considered as a neurodevelopmental anomaly that may contribute to neuropsychiatric abnormalities . It is often of incidental finding, of little clinical significance. However, an association between this developmental anomaly and a mental disorder, such as schizophrenia and/or intellectual disability, has been reported
Objectives
The objective of this study is to discuss the relationship between the septum pellucidum cyst and mental disorders, especially schizophrenia and intellectual disability.
Methods
We report in this study two clinical cases, diagnosed with schizophrenia comorbid with intellectual disability and in whom brain imaging has objectified a cyst of the septum pellucidum
Results
multiple cases reports of patients with Schizophrenia and/or mental retardation revealed, on brain imaging, significant abnormalities in midline brain regions such as Septum Pellucidum. It is suggested that CSP, particularly if large, should be considered a developmental anomaly that may contribute to neuropsychiatric abnormalities.
Conclusions
Whether the CSP may serve as a risk factor for psychosis or is only a reflection of neuroanatomical changes in individuals with chronic psychotic disorders remains ambiguous. More studies and case reports will be needed to establish the veritable association of CSP and neuropsychiatric disorders in the future, and perhaps to acknowledge the CSP as an early marker and predictor of psychosis.
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:34:59Z |
| format | Article |
| id | doaj.art-7ec0ef82806c4e83b1beaef142020a13 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:34:59Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-7ec0ef82806c4e83b1beaef142020a132023-11-17T05:10:09ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S923S92410.1192/j.eurpsy.2023.1953Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reportsM. Belak0pedopsychiatric, psychiatric hospital Arrazi, salé, Morocco Introduction A septum pellucidum cyst is defined as a fluid collection between the lateral ventricles whose walls have a lateral curvature and are separated by 10 mm or more . Most of these cysts are benign and their clinical significance should be considered as a neurodevelopmental anomaly that may contribute to neuropsychiatric abnormalities . It is often of incidental finding, of little clinical significance. However, an association between this developmental anomaly and a mental disorder, such as schizophrenia and/or intellectual disability, has been reported Objectives The objective of this study is to discuss the relationship between the septum pellucidum cyst and mental disorders, especially schizophrenia and intellectual disability. Methods We report in this study two clinical cases, diagnosed with schizophrenia comorbid with intellectual disability and in whom brain imaging has objectified a cyst of the septum pellucidum Results multiple cases reports of patients with Schizophrenia and/or mental retardation revealed, on brain imaging, significant abnormalities in midline brain regions such as Septum Pellucidum. It is suggested that CSP, particularly if large, should be considered a developmental anomaly that may contribute to neuropsychiatric abnormalities. Conclusions Whether the CSP may serve as a risk factor for psychosis or is only a reflection of neuroanatomical changes in individuals with chronic psychotic disorders remains ambiguous. More studies and case reports will be needed to establish the veritable association of CSP and neuropsychiatric disorders in the future, and perhaps to acknowledge the CSP as an early marker and predictor of psychosis. Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823019533/type/journal_article |
| spellingShingle | M. Belak Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports European Psychiatry |
| title | Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports |
| title_full | Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports |
| title_fullStr | Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports |
| title_full_unstemmed | Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports |
| title_short | Cyst of Septum Pellucidum in mental disorders: Schizophrenia and Mental Retardation: Two case reports |
| title_sort | cyst of septum pellucidum in mental disorders schizophrenia and mental retardation two case reports |
| url | https://www.cambridge.org/core/product/identifier/S0924933823019533/type/journal_article |
| work_keys_str_mv | AT mbelak cystofseptumpelluciduminmentaldisordersschizophreniaandmentalretardationtwocasereports |