Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients
The pathogenesis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) differs according to whether prior treatment with interferon (IFN) vs. direct-acting antiviral agents (DAAs) was administered. Cyclo- oxygenase-2 (COX-2), yes-associated protein 1 (YAP), and transcriptional co-activat...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2022-08-01
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| Series: | Polish Journal of Pathology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Expression-of-cyclo-oxygenase-2-and-yap-taz-in-hepatocellular-carcinoma-in-untreated-and-treated-hepatitis-C-virus-patients,55,47623,1,1.html |
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| author | Dina Sweed Aya Abd-Elbary Eman Sweed Asmaa Mosbeh Inas Moaz Taha Yassein Shereen Elmashad |
| author_facet | Dina Sweed Aya Abd-Elbary Eman Sweed Asmaa Mosbeh Inas Moaz Taha Yassein Shereen Elmashad |
| author_sort | Dina Sweed |
| collection | DOAJ |
| description | The pathogenesis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) differs according to whether prior treatment with interferon (IFN) vs. direct-acting antiviral agents (DAAs) was administered. Cyclo- oxygenase-2 (COX-2), yes-associated protein 1 (YAP), and transcriptional co-activator with PDZ-binding motif (TAZ) play a crucial role in hepatocarcinogenesis. However, their roles in untreated or treated HCV-related HCC development have not been clarified.
Therefore, we performed an immunohistochemical study and stained tissue from 83 HCV-related HCC cases using antibodies against COX-2, YAP, and TAZ and correlated their expression with the clinicopathological characteri stics and survival data.
The cases were subdivided into 3 groups based on prior HCV treatment. In the 3 groups, COX-2 was significantly higher in HCC tissue compared with adjacent non-tumour liver tissue. However, the expression of YAP/TAZ was not significantly different between HCC and adjacent non-tumour tissue. We further grouped HCC cases into YAP+/TAZ+ and YAP–/TAZ– cases.
In the YAP+/TAZ+ cases, COX-2 was significantly associated with tumour size, tumour multifocality, and late pathologic stage. No significant difference was observed in COX-2 and TAZ expression as a result of IFN or DAA treatment; however, YAP was significantly higher in IFN-treated HCC. Cyclo-oxygenase-2 overexpression may play a role in late HCC development, while YAP/TAZ could play an early role in HCC progression. Sustained expression of combined YAP/TAZ could mediate the poor prognostic role of COX-2. |
| first_indexed | 2024-04-10T20:23:14Z |
| format | Article |
| id | doaj.art-7ec1ed4501984ecf9cd0169da0ed4489 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-04-10T20:23:14Z |
| publishDate | 2022-08-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-7ec1ed4501984ecf9cd0169da0ed44892023-01-25T13:42:38ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692022-08-01732889810.5114/pjp.2022.11870047623Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patientsDina SweedAya Abd-ElbaryEman SweedAsmaa MosbehInas MoazTaha YasseinShereen ElmashadThe pathogenesis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) differs according to whether prior treatment with interferon (IFN) vs. direct-acting antiviral agents (DAAs) was administered. Cyclo- oxygenase-2 (COX-2), yes-associated protein 1 (YAP), and transcriptional co-activator with PDZ-binding motif (TAZ) play a crucial role in hepatocarcinogenesis. However, their roles in untreated or treated HCV-related HCC development have not been clarified. Therefore, we performed an immunohistochemical study and stained tissue from 83 HCV-related HCC cases using antibodies against COX-2, YAP, and TAZ and correlated their expression with the clinicopathological characteri stics and survival data. The cases were subdivided into 3 groups based on prior HCV treatment. In the 3 groups, COX-2 was significantly higher in HCC tissue compared with adjacent non-tumour liver tissue. However, the expression of YAP/TAZ was not significantly different between HCC and adjacent non-tumour tissue. We further grouped HCC cases into YAP+/TAZ+ and YAP–/TAZ– cases. In the YAP+/TAZ+ cases, COX-2 was significantly associated with tumour size, tumour multifocality, and late pathologic stage. No significant difference was observed in COX-2 and TAZ expression as a result of IFN or DAA treatment; however, YAP was significantly higher in IFN-treated HCC. Cyclo-oxygenase-2 overexpression may play a role in late HCC development, while YAP/TAZ could play an early role in HCC progression. Sustained expression of combined YAP/TAZ could mediate the poor prognostic role of COX-2.https://www.termedia.pl/Expression-of-cyclo-oxygenase-2-and-yap-taz-in-hepatocellular-carcinoma-in-untreated-and-treated-hepatitis-C-virus-patients,55,47623,1,1.htmlcox-2 hcv hepatocellular carcinoma taz yap. |
| spellingShingle | Dina Sweed Aya Abd-Elbary Eman Sweed Asmaa Mosbeh Inas Moaz Taha Yassein Shereen Elmashad Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients Polish Journal of Pathology cox-2 hcv hepatocellular carcinoma taz yap. |
| title | Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients |
| title_full | Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients |
| title_fullStr | Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients |
| title_full_unstemmed | Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients |
| title_short | Expression of cyclo-oxygenase-2 and yap/taz in hepatocellular carcinoma in untreated and treated hepatitis C virus patients |
| title_sort | expression of cyclo oxygenase 2 and yap taz in hepatocellular carcinoma in untreated and treated hepatitis c virus patients |
| topic | cox-2 hcv hepatocellular carcinoma taz yap. |
| url | https://www.termedia.pl/Expression-of-cyclo-oxygenase-2-and-yap-taz-in-hepatocellular-carcinoma-in-untreated-and-treated-hepatitis-C-virus-patients,55,47623,1,1.html |
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