There and Back Again: Leptin Actions in White Adipose Tissue
Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6039 |
| _version_ | 1797556303450603520 |
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| author | Noelia Martínez-Sánchez |
| author_facet | Noelia Martínez-Sánchez |
| author_sort | Noelia Martínez-Sánchez |
| collection | DOAJ |
| description | Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectations for the treatment of the obesity, and on the other, it changed the classical concept that white adipose tissue was simply an inert storage organ. Thus, adipocytes in WAT produce the majority of leptin and, although its primary role is the regulation of fat stores by controlling lipolysis and lipogenesis, this hormone also has implications in other physiological processes within WAT, such as apoptosis, browning and inflammation. Although a massive number of questions related to leptin actions have been answered, the necessity for further clarification facilitates constantly renewing interest in this hormone and its pathways. In this review, leptin actions in white adipose tissue will be summarized in the context of obesity. |
| first_indexed | 2024-03-10T17:00:54Z |
| format | Article |
| id | doaj.art-7ec3078cb0d3475b8b3adce01b0f948d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:00:54Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7ec3078cb0d3475b8b3adce01b0f948d2023-11-20T10:58:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117603910.3390/ijms21176039There and Back Again: Leptin Actions in White Adipose TissueNoelia Martínez-Sánchez0Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UKLeptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectations for the treatment of the obesity, and on the other, it changed the classical concept that white adipose tissue was simply an inert storage organ. Thus, adipocytes in WAT produce the majority of leptin and, although its primary role is the regulation of fat stores by controlling lipolysis and lipogenesis, this hormone also has implications in other physiological processes within WAT, such as apoptosis, browning and inflammation. Although a massive number of questions related to leptin actions have been answered, the necessity for further clarification facilitates constantly renewing interest in this hormone and its pathways. In this review, leptin actions in white adipose tissue will be summarized in the context of obesity.https://www.mdpi.com/1422-0067/21/17/6039leptinwhite adipose tissueobesity |
| spellingShingle | Noelia Martínez-Sánchez There and Back Again: Leptin Actions in White Adipose Tissue International Journal of Molecular Sciences leptin white adipose tissue obesity |
| title | There and Back Again: Leptin Actions in White Adipose Tissue |
| title_full | There and Back Again: Leptin Actions in White Adipose Tissue |
| title_fullStr | There and Back Again: Leptin Actions in White Adipose Tissue |
| title_full_unstemmed | There and Back Again: Leptin Actions in White Adipose Tissue |
| title_short | There and Back Again: Leptin Actions in White Adipose Tissue |
| title_sort | there and back again leptin actions in white adipose tissue |
| topic | leptin white adipose tissue obesity |
| url | https://www.mdpi.com/1422-0067/21/17/6039 |
| work_keys_str_mv | AT noeliamartinezsanchez thereandbackagainleptinactionsinwhiteadiposetissue |