MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma
<p>Abstract</p> <p>MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0/G1 ar...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-08-01
|
| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | http://www.jeccr.com/content/30/1/73 |
| _version_ | 1811285176515297280 |
|---|---|
| author | Bao Xueli Wang Yu Cai Kemin |
| author_facet | Bao Xueli Wang Yu Cai Kemin |
| author_sort | Bao Xueli |
| collection | DOAJ |
| description | <p>Abstract</p> <p>MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0/G1 arrest by targeting tumor suppressor RB in human laryngeal carcinoma cells. Further, Introducing RB cDNA without 3'UTR abrogated miR-106b-induced cell proliferation. Finally, there was an inverse relationship between RB and miR-106b expression in laryngeal carcinoma tissues. To our knowledge, these data indicate for the first time that miR-106b directly regulate cell cycle by targeting RB in laryngeal carcinoma and that miR-106b could be potential therapeutic approaches for laryngeal carcinoma.</p> |
| first_indexed | 2024-04-13T02:40:29Z |
| format | Article |
| id | doaj.art-7ec50f984bd948a6a63a3e876d8a678b |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-13T02:40:29Z |
| publishDate | 2011-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-7ec50f984bd948a6a63a3e876d8a678b2022-12-22T03:06:13ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662011-08-013017310.1186/1756-9966-30-73MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinomaBao XueliWang YuCai Kemin<p>Abstract</p> <p>MiR-106b is frequently up-regulated in various types of human cancer including laryngeal carcinoma. However the underlying mechanism of miR-106b involved in laryngeal carcinoma remains elusive. Here we showed that reduction of miR-106b induced cell cycle G0/G1 arrest by targeting tumor suppressor RB in human laryngeal carcinoma cells. Further, Introducing RB cDNA without 3'UTR abrogated miR-106b-induced cell proliferation. Finally, there was an inverse relationship between RB and miR-106b expression in laryngeal carcinoma tissues. To our knowledge, these data indicate for the first time that miR-106b directly regulate cell cycle by targeting RB in laryngeal carcinoma and that miR-106b could be potential therapeutic approaches for laryngeal carcinoma.</p>http://www.jeccr.com/content/30/1/73laryngeal carcinomamiR-106bRBcell proliferation |
| spellingShingle | Bao Xueli Wang Yu Cai Kemin MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma Journal of Experimental & Clinical Cancer Research laryngeal carcinoma miR-106b RB cell proliferation |
| title | MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma |
| title_full | MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma |
| title_fullStr | MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma |
| title_full_unstemmed | MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma |
| title_short | MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma |
| title_sort | mir 106b promotes cell proliferation via targeting rb in laryngeal carcinoma |
| topic | laryngeal carcinoma miR-106b RB cell proliferation |
| url | http://www.jeccr.com/content/30/1/73 |
| work_keys_str_mv | AT baoxueli mir106bpromotescellproliferationviatargetingrbinlaryngealcarcinoma AT wangyu mir106bpromotescellproliferationviatargetingrbinlaryngealcarcinoma AT caikemin mir106bpromotescellproliferationviatargetingrbinlaryngealcarcinoma |