The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions
Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic proportions. This family of peptides represents...
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| Format: | Artykuł |
| Język: | English |
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MDPI AG
2023-02-01
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| Seria: | Molecules |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.mdpi.com/1420-3049/28/5/2156 |
| _version_ | 1827752460772442112 |
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| author | Caroline Donaghy Jose Gabriel Javellana Young-Jin Hong Karrera Djoko Alfredo M. Angeles-Boza |
| author_facet | Caroline Donaghy Jose Gabriel Javellana Young-Jin Hong Karrera Djoko Alfredo M. Angeles-Boza |
| author_sort | Caroline Donaghy |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic proportions. This family of peptides represents a promising alternative to current antibiotics due to their broad-spectrum antimicrobial activity and tendency to avoid resistance development. A subfamily of AMPs interacts with metal ions to potentiate antimicrobial effectiveness, and, as such, they have been termed metalloAMPs. In this work, we review the scientific literature on metalloAMPs that enhance their antimicrobial efficacy when combined with the essential metal ion zinc(II). Beyond the role played by Zn(II) as a cofactor in different systems, it is well-known that this metal ion plays an important role in innate immunity. Here, we classify the different types of synergistic interactions between AMPs and Zn(II) into three distinct classes. By better understanding how each class of metalloAMPs uses Zn(II) to potentiate its activity, researchers can begin to exploit these interactions in the development of new antimicrobial agents and accelerate their use as therapeutics. |
| first_indexed | 2024-03-11T07:17:43Z |
| format | Article |
| id | doaj.art-7ec5369daa3d44aabe38ba55c52e86f2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T07:17:43Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7ec5369daa3d44aabe38ba55c52e86f22023-11-17T08:12:46ZengMDPI AGMolecules1420-30492023-02-01285215610.3390/molecules28052156The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic InteractionsCaroline Donaghy0Jose Gabriel Javellana1Young-Jin Hong2Karrera Djoko3Alfredo M. Angeles-Boza4Department of Chemistry, University of Connecticut, Storrs, CT 06269, USADepartment of Chemistry, University of Connecticut, Storrs, CT 06269, USADepartment of Chemistry, Durham University, Durham DH1 3LE, UKDepartment of Chemistry, Durham University, Durham DH1 3LE, UKDepartment of Chemistry, University of Connecticut, Storrs, CT 06269, USAAntimicrobial peptides (AMPs) are essential components of innate immunity across all species. AMPs have become the focus of attention in recent years, as scientists are addressing antibiotic resistance, a public health crisis that has reached epidemic proportions. This family of peptides represents a promising alternative to current antibiotics due to their broad-spectrum antimicrobial activity and tendency to avoid resistance development. A subfamily of AMPs interacts with metal ions to potentiate antimicrobial effectiveness, and, as such, they have been termed metalloAMPs. In this work, we review the scientific literature on metalloAMPs that enhance their antimicrobial efficacy when combined with the essential metal ion zinc(II). Beyond the role played by Zn(II) as a cofactor in different systems, it is well-known that this metal ion plays an important role in innate immunity. Here, we classify the different types of synergistic interactions between AMPs and Zn(II) into three distinct classes. By better understanding how each class of metalloAMPs uses Zn(II) to potentiate its activity, researchers can begin to exploit these interactions in the development of new antimicrobial agents and accelerate their use as therapeutics.https://www.mdpi.com/1420-3049/28/5/2156antimicrobial peptideshost defense peptideszincmetalloAMPs |
| spellingShingle | Caroline Donaghy Jose Gabriel Javellana Young-Jin Hong Karrera Djoko Alfredo M. Angeles-Boza The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions Molecules antimicrobial peptides host defense peptides zinc metalloAMPs |
| title | The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions |
| title_full | The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions |
| title_fullStr | The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions |
| title_full_unstemmed | The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions |
| title_short | The Synergy between Zinc and Antimicrobial Peptides: An Insight into Unique Bioinorganic Interactions |
| title_sort | synergy between zinc and antimicrobial peptides an insight into unique bioinorganic interactions |
| topic | antimicrobial peptides host defense peptides zinc metalloAMPs |
| url | https://www.mdpi.com/1420-3049/28/5/2156 |
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