Sensitization to indoor allergens and frequency of asthma exacerbations in children
Background The rapid increase in asthma incidence has implicated the importance of environmental influences over genetic influences. Sensitization to perennial indoor allergens has been associated with increased asthma symptoms. Objective To examine the correlation between sensitization to indoor a...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2011-08-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/871 |
| _version_ | 1811202088615542784 |
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| author | Irene Irene Putu Siadi Purniti Sumadiono Sumadiono |
| author_facet | Irene Irene Putu Siadi Purniti Sumadiono Sumadiono |
| author_sort | Irene Irene |
| collection | DOAJ |
| description | Background The rapid increase in asthma incidence has implicated the importance of environmental influences over genetic influences. Sensitization to perennial indoor allergens has been associated with increased asthma symptoms.
Objective To examine the correlation between sensitization to indoor allergens and frequency of asthma exacerbations in children.
Methods A cross-sectional study was carried out on asthmatic children aged 6 to 12 years in the Department of Child Health, Udayana University Medical School /Sanglah Hospital, Denpasar. Degree of sensitization was assessed by mean wheal diameter (positive defined as 3 mm greater than negative control) for seven common indoor allergens. Frequency of asthma exacerbation for three consecutive months prior to data collection was retrospectively reviewed.
Results Positive skin test results for one or more allergens were found in 84 of 89 (94%) asthmatic children. Higher frequency of asthma exacerbations weakly correlated with the number of allergens with positive sensitization (r=0.284; P=0.007). Mean wheal diameter of each allergen did not correlate to the frequency of asthma exacerbations. In addition, the frequency of asthma exacerbations was independent for parental and sibling atopic history, preceding respiratory infections, use of asthma controllers and passive environmental tobacco smoke exposure.
Conclusions Sensitization to common indoor allergens correlates weakly with frequency of asthma exacerbations. |
| first_indexed | 2024-04-12T02:33:14Z |
| format | Article |
| id | doaj.art-7ec556adc85c44aa982b516b6aeaa5b5 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-04-12T02:33:14Z |
| publishDate | 2011-08-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-7ec556adc85c44aa982b516b6aeaa5b52022-12-22T03:51:40ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2011-08-015142071210.14238/pi51.4.2011.207-12732Sensitization to indoor allergens and frequency of asthma exacerbations in childrenIrene Irene0Putu Siadi Purniti1Sumadiono Sumadiono2Department of Child Health, Udayana University Medical School/Sanglah Hospital, Denpasar, BaliDepartment of Child Health, Udayana University Medical School/Sanglah Hospital, Denpasar, BaliDepartment of Child Health, Gadjah Mada University Medical School/Dr. Sardjito Hospital, Yogyakarta, Central JavaBackground The rapid increase in asthma incidence has implicated the importance of environmental influences over genetic influences. Sensitization to perennial indoor allergens has been associated with increased asthma symptoms. Objective To examine the correlation between sensitization to indoor allergens and frequency of asthma exacerbations in children. Methods A cross-sectional study was carried out on asthmatic children aged 6 to 12 years in the Department of Child Health, Udayana University Medical School /Sanglah Hospital, Denpasar. Degree of sensitization was assessed by mean wheal diameter (positive defined as 3 mm greater than negative control) for seven common indoor allergens. Frequency of asthma exacerbation for three consecutive months prior to data collection was retrospectively reviewed. Results Positive skin test results for one or more allergens were found in 84 of 89 (94%) asthmatic children. Higher frequency of asthma exacerbations weakly correlated with the number of allergens with positive sensitization (r=0.284; P=0.007). Mean wheal diameter of each allergen did not correlate to the frequency of asthma exacerbations. In addition, the frequency of asthma exacerbations was independent for parental and sibling atopic history, preceding respiratory infections, use of asthma controllers and passive environmental tobacco smoke exposure. Conclusions Sensitization to common indoor allergens correlates weakly with frequency of asthma exacerbations.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/871asthma exacerbationsensitizationindoor allergen |
| spellingShingle | Irene Irene Putu Siadi Purniti Sumadiono Sumadiono Sensitization to indoor allergens and frequency of asthma exacerbations in children Paediatrica Indonesiana asthma exacerbation sensitization indoor allergen |
| title | Sensitization to indoor allergens and frequency of asthma exacerbations in children |
| title_full | Sensitization to indoor allergens and frequency of asthma exacerbations in children |
| title_fullStr | Sensitization to indoor allergens and frequency of asthma exacerbations in children |
| title_full_unstemmed | Sensitization to indoor allergens and frequency of asthma exacerbations in children |
| title_short | Sensitization to indoor allergens and frequency of asthma exacerbations in children |
| title_sort | sensitization to indoor allergens and frequency of asthma exacerbations in children |
| topic | asthma exacerbation sensitization indoor allergen |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/871 |
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