Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.
Travel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown.To investigate the effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.In 51 healthy...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3731354?pdf=render |
| _version_ | 1819154450982371328 |
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| author | Anne-Christin Stöwhas Tsogyal D Latshang Christian M Lo Cascio Sina Lautwein Katrin Stadelmann Noemi Tesler Lisa Ayers Kaspar Berneis Philipp A Gerber Reto Huber Peter Achermann Konrad E Bloch Malcolm Kohler |
| author_facet | Anne-Christin Stöwhas Tsogyal D Latshang Christian M Lo Cascio Sina Lautwein Katrin Stadelmann Noemi Tesler Lisa Ayers Kaspar Berneis Philipp A Gerber Reto Huber Peter Achermann Konrad E Bloch Malcolm Kohler |
| author_sort | Anne-Christin Stöwhas |
| collection | DOAJ |
| description | Travel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown.To investigate the effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.In 51 healthy male subjects with a mean (SD) age of 26.9 (9.3) years, oxygen saturation, blood pressure, heart rate, arterial stiffness, lipid profiles, low density lipoprotein (LDL) particle size, insulin resistance (HOMA-index), highly-sensitive C-reactive protein and pro-inflammatory cytokines were measured at 490 m (Zurich) and during two days at 2590 m, (Davos Jakobshorn, Switzerland) in randomized order. The largest differences in outcomes between the two altitudes are reported.Mean (SD) oxygen saturation was significantly lower at 2590 m, 91.0 (2.0)%, compared to 490 m, 96.0 (1.0)%, p<0.001. Mean blood pressure (mean difference +4.8 mmHg, p<0.001) and heart rate (mean difference +3.3 bpm, p<0.001) were significantly higher at 2590 m, compared to 490 m, but this was not associated with increased arterial stiffness. At 2590 m, lipid profiles improved (median difference triglycerides -0.14 mmol/l, p=0.012, HDL +0.08 mmol/l, p<0.001, total cholesterol/HDL-ratio -0.25, p=0.001), LDL particle size increased (median difference +0.45 nm, p=0.048) and hsCRP decreased (median difference -0.18 mg/l, p=0.024) compared to 490 m. No significant change in pro-inflammatory cytokines or insulin resistance was observed upon ascent to 2590 m.Short-term stay at moderate altitude is associated with increased blood pressure and heart rate likely due to augmented sympathetic activity. Exposure to moderate altitude improves the lipid profile and systemic inflammation, but seems to have no significant effect on glucose metabolism.ClinicalTrials.gov NCT01130948. |
| first_indexed | 2024-12-22T15:21:17Z |
| format | Article |
| id | doaj.art-7ec64f34d416499f85d59f04b17b86bf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T15:21:17Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7ec64f34d416499f85d59f04b17b86bf2022-12-21T18:21:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0188e7008110.1371/journal.pone.0070081Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.Anne-Christin StöwhasTsogyal D LatshangChristian M Lo CascioSina LautweinKatrin StadelmannNoemi TeslerLisa AyersKaspar BerneisPhilipp A GerberReto HuberPeter AchermannKonrad E BlochMalcolm KohlerTravel to mountain areas is popular. However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown.To investigate the effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation.In 51 healthy male subjects with a mean (SD) age of 26.9 (9.3) years, oxygen saturation, blood pressure, heart rate, arterial stiffness, lipid profiles, low density lipoprotein (LDL) particle size, insulin resistance (HOMA-index), highly-sensitive C-reactive protein and pro-inflammatory cytokines were measured at 490 m (Zurich) and during two days at 2590 m, (Davos Jakobshorn, Switzerland) in randomized order. The largest differences in outcomes between the two altitudes are reported.Mean (SD) oxygen saturation was significantly lower at 2590 m, 91.0 (2.0)%, compared to 490 m, 96.0 (1.0)%, p<0.001. Mean blood pressure (mean difference +4.8 mmHg, p<0.001) and heart rate (mean difference +3.3 bpm, p<0.001) were significantly higher at 2590 m, compared to 490 m, but this was not associated with increased arterial stiffness. At 2590 m, lipid profiles improved (median difference triglycerides -0.14 mmol/l, p=0.012, HDL +0.08 mmol/l, p<0.001, total cholesterol/HDL-ratio -0.25, p=0.001), LDL particle size increased (median difference +0.45 nm, p=0.048) and hsCRP decreased (median difference -0.18 mg/l, p=0.024) compared to 490 m. No significant change in pro-inflammatory cytokines or insulin resistance was observed upon ascent to 2590 m.Short-term stay at moderate altitude is associated with increased blood pressure and heart rate likely due to augmented sympathetic activity. Exposure to moderate altitude improves the lipid profile and systemic inflammation, but seems to have no significant effect on glucose metabolism.ClinicalTrials.gov NCT01130948.http://europepmc.org/articles/PMC3731354?pdf=render |
| spellingShingle | Anne-Christin Stöwhas Tsogyal D Latshang Christian M Lo Cascio Sina Lautwein Katrin Stadelmann Noemi Tesler Lisa Ayers Kaspar Berneis Philipp A Gerber Reto Huber Peter Achermann Konrad E Bloch Malcolm Kohler Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. PLoS ONE |
| title | Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. |
| title_full | Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. |
| title_fullStr | Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. |
| title_full_unstemmed | Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. |
| title_short | Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. |
| title_sort | effects of acute exposure to moderate altitude on vascular function metabolism and systemic inflammation |
| url | http://europepmc.org/articles/PMC3731354?pdf=render |
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