The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis
Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the L...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1026 |
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| author | Susana Coimbra Cristina Catarino Maria Sameiro Faria José Pedro L. Nunes Susana Rocha Maria João Valente Petronila Rocha-Pereira Elsa Bronze-da-Rocha Nuno Bettencourt Ana Beco Sofia Homem de Melo Marques José Gerardo Oliveira José Madureira João Carlos Fernandes Vasco Miranda Luís Belo Alice Santos-Silva |
| author_facet | Susana Coimbra Cristina Catarino Maria Sameiro Faria José Pedro L. Nunes Susana Rocha Maria João Valente Petronila Rocha-Pereira Elsa Bronze-da-Rocha Nuno Bettencourt Ana Beco Sofia Homem de Melo Marques José Gerardo Oliveira José Madureira João Carlos Fernandes Vasco Miranda Luís Belo Alice Santos-Silva |
| author_sort | Susana Coimbra |
| collection | DOAJ |
| description | Left ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (<i>n</i> = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients. |
| first_indexed | 2024-03-11T05:13:08Z |
| format | Article |
| id | doaj.art-7ec9ae66c1f34b2b8dddcf2426efd768 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:13:08Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7ec9ae66c1f34b2b8dddcf2426efd7682023-11-17T18:25:29ZengMDPI AGBiomedicines2227-90592023-03-01114102610.3390/biomedicines11041026The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on DialysisSusana Coimbra0Cristina Catarino1Maria Sameiro Faria2José Pedro L. Nunes3Susana Rocha4Maria João Valente5Petronila Rocha-Pereira6Elsa Bronze-da-Rocha7Nuno Bettencourt8Ana Beco9Sofia Homem de Melo Marques10José Gerardo Oliveira11José Madureira12João Carlos Fernandes13Vasco Miranda14Luís Belo15Alice Santos-Silva16UCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalFaculty of Medicine, University of Porto, 4200-319 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalFaculty of Medicine, University of Porto, 4200-319 Porto, PortugalHemodialysis Clinic Hospital Agostinho Ribeiro, 4610-106 Felgueiras, PortugalHemodialysis Clinic Hospital Agostinho Ribeiro, 4610-106 Felgueiras, PortugalHemodialysis Clinic of Porto (CHP), 4200-227 Porto, PortugalNefroServe, Hemodialysis Clinic of Barcelos, 4750-110 Barcelos, PortugalNefroServe Hemodialysis Clinic of Viana do Castelo, 4900-281 Viana do Castelo, PortugalHemodialysis Clinic of Gondomar, 4420-086 Gondomar, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalUCIBIO—Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculdade de Farmácia, Universidade do Porto, 4050-313 Porto, PortugalLeft ventricular hypertrophy (LVH) is a common cardiovascular complication in end-stage kidney disease (ESKD) patients. We aimed at studying the association of LVH with adiponectin and leptin levels, cardiovascular stress/injury biomarkers and nutritional status in these patients. We evaluated the LV mass (LVM) and calculated the LVM index (LVMI) in 196 ESKD patients on dialysis; the levels of hemoglobin, calcium, phosphorus, parathyroid hormone, albumin, adiponectin, leptin, N-terminal pro B-type natriuretic peptide (NT-proBNP) and growth differentiation factor (GDF)-15 were analyzed. ESKD patients with LVH (<i>n</i> = 131) presented higher NT-proBNP and GDF-15, lower hemoglobin and, after adjustment for gender, lower leptin levels compared with non-LVH patients. LVH females also showed lower leptin than the non-LVH female group. In the LVH group, LVMI presented a negative correlation with leptin and a positive correlation with NT-proBNP. Leptin emerged as an independent determinant of LVMI in both groups, and NT-proBNP in the LVH group. Low hemoglobin and leptin and increased calcium, NT-proBNP and dialysis vintage are associated with an increased risk of developing LVH. In ESKD patients on dialysis, LVH is associated with lower leptin values (especially in women), which are negatively correlated with LVMI, and with higher levels of biomarkers of myocardial stress/injury. Leptin and NT-proBNP appear as independent determinants of LVMI; dialysis vintage, hemoglobin, calcium, NT-proBNP and leptin emerged as predicting markers for LVH development. Further studies are needed to better understand the role of leptin in LVH in ESKD patients.https://www.mdpi.com/2227-9059/11/4/1026leptinleft ventricular mass indexNT-proBNPhemoglobincalciumGDF-15 |
| spellingShingle | Susana Coimbra Cristina Catarino Maria Sameiro Faria José Pedro L. Nunes Susana Rocha Maria João Valente Petronila Rocha-Pereira Elsa Bronze-da-Rocha Nuno Bettencourt Ana Beco Sofia Homem de Melo Marques José Gerardo Oliveira José Madureira João Carlos Fernandes Vasco Miranda Luís Belo Alice Santos-Silva The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis Biomedicines leptin left ventricular mass index NT-proBNP hemoglobin calcium GDF-15 |
| title | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
| title_full | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
| title_fullStr | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
| title_full_unstemmed | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
| title_short | The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis |
| title_sort | association of leptin with left ventricular hypertrophy in end stage kidney disease patients on dialysis |
| topic | leptin left ventricular mass index NT-proBNP hemoglobin calcium GDF-15 |
| url | https://www.mdpi.com/2227-9059/11/4/1026 |
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