The Potential Protective Effect and Underlying Mechanisms of Physiological Unconjugated Hyperbilirubinemia Mediated by UGT1A1 Antisense Oligonucleotide Therapy in a Mouse Model of Cyclosporine A-Induced Chronic Kidney Disease

The Potential Protective Effect and Underlying Mechanisms of Physiological Unconjugated Hyperbilirubinemia Mediated by UGT1A1 Antisense Oligonucleotide Therapy in a Mouse Model of Cyclosporine A-Induced Chronic Kidney Disease

Cyclosporine A (CSA) is an immunosuppressive drug that has improved transplant survival rates. However, its use is often limited because it is thought to be linked to the development of chronic kidney disease after kidney transplants. This study aimed to investigate the protective effects and underl...

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Bibliographic Details
Main Authors: Basma H. Marghani, Mohamed El-Adl, Ahmed I. Ateya, Basma H. Othman, Heba I. Ghamry, Mustafa Shukry, Mohamed Mohamed Soliman, Mohamed Abdo Rizk
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Metabolites
Subjects:
cyclosporine A
chronic kidney disease
oxidative stress
UGT1A1 antisense
mild unconjugated hyperbilirubinemia
Online Access:https://www.mdpi.com/2218-1989/12/10/999

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