Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation
Abstract Radiation‐induced lung damage (RILD) is a critical problem in lung cancer radiotherapy, and it is difficult to predict its severity. Although no biomarkers for RILD have been established, tenascin C (TNC) is an extracellular matrix glycoprotein involved in the remodeling of damaged tissues...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14624 |
| _version_ | 1811251295860817920 |
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| author | Yutaka Toyomasu Kenta Matsui Kazuki Omori Akinori Takada Kyoko Imanaka‐Yoshida Isao Tawara Akira Shimamoto Motoshi Takao Hiroyasu Kobayashi Atsushi Tomaru Hajime Fujimoto Tetsu Kobayashi Haiime Sakuma Yoshihito Nomoto |
| author_facet | Yutaka Toyomasu Kenta Matsui Kazuki Omori Akinori Takada Kyoko Imanaka‐Yoshida Isao Tawara Akira Shimamoto Motoshi Takao Hiroyasu Kobayashi Atsushi Tomaru Hajime Fujimoto Tetsu Kobayashi Haiime Sakuma Yoshihito Nomoto |
| author_sort | Yutaka Toyomasu |
| collection | DOAJ |
| description | Abstract Radiation‐induced lung damage (RILD) is a critical problem in lung cancer radiotherapy, and it is difficult to predict its severity. Although no biomarkers for RILD have been established, tenascin C (TNC) is an extracellular matrix glycoprotein involved in the remodeling of damaged tissues and has been implicated in inflammation and fibrosis. We report the unique case of a 36‐year‐old man with adenocarcinoma of the lung, Union for International Cancer Control stage IIIB, who was treated with radiotherapy before lung surgery. The surgical specimen showed histopathological expression of TNC in the region where radiation pneumonitis was observed radiographically. Serum TNC levels were elevated after radiotherapy. In this case, TNC is suggested to be implicated in RILD and may be a potential candidate as a biomarker for the onset and severity of the condition. |
| first_indexed | 2024-04-12T16:17:21Z |
| format | Article |
| id | doaj.art-7ecba493802b4aa09259857a7537e90a |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-12T16:17:21Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-7ecba493802b4aa09259857a7537e90a2022-12-22T03:25:41ZengWileyThoracic Cancer1759-77061759-77142022-10-0113202904290710.1111/1759-7714.14624Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevationYutaka Toyomasu0Kenta Matsui1Kazuki Omori2Akinori Takada3Kyoko Imanaka‐Yoshida4Isao Tawara5Akira Shimamoto6Motoshi Takao7Hiroyasu Kobayashi8Atsushi Tomaru9Hajime Fujimoto10Tetsu Kobayashi11Haiime Sakuma12Yoshihito Nomoto13Department of Radiology Mie University Tsu JapanDepartment of Pathology and Matrix Biology Mie University Tsu JapanDepartment of Radiology Mie University Tsu JapanDepartment of Radiology Mie University Tsu JapanDepartment of Pathology and Matrix Biology Mie University Tsu JapanDepartment of Hematology and Oncology Mie University Tsu JapanDepartment of Thoracic Surgery Mie University Tsu JapanDepartment of Thoracic Surgery Mie University Tsu JapanDepartment of Respiratory Medicine Mie University Tsu JapanDepartment of Respiratory Medicine Mie University Tsu JapanDepartment of Respiratory Medicine Mie University Tsu JapanDepartment of Respiratory Medicine Mie University Tsu JapanDepartment of Radiology Mie University Tsu JapanDepartment of Radiology Mie University Tsu JapanAbstract Radiation‐induced lung damage (RILD) is a critical problem in lung cancer radiotherapy, and it is difficult to predict its severity. Although no biomarkers for RILD have been established, tenascin C (TNC) is an extracellular matrix glycoprotein involved in the remodeling of damaged tissues and has been implicated in inflammation and fibrosis. We report the unique case of a 36‐year‐old man with adenocarcinoma of the lung, Union for International Cancer Control stage IIIB, who was treated with radiotherapy before lung surgery. The surgical specimen showed histopathological expression of TNC in the region where radiation pneumonitis was observed radiographically. Serum TNC levels were elevated after radiotherapy. In this case, TNC is suggested to be implicated in RILD and may be a potential candidate as a biomarker for the onset and severity of the condition.https://doi.org/10.1111/1759-7714.14624radiation fibrosisradiation induced lung damageradiation pneumonitistenascin C |
| spellingShingle | Yutaka Toyomasu Kenta Matsui Kazuki Omori Akinori Takada Kyoko Imanaka‐Yoshida Isao Tawara Akira Shimamoto Motoshi Takao Hiroyasu Kobayashi Atsushi Tomaru Hajime Fujimoto Tetsu Kobayashi Haiime Sakuma Yoshihito Nomoto Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation Thoracic Cancer radiation fibrosis radiation induced lung damage radiation pneumonitis tenascin C |
| title | Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation |
| title_full | Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation |
| title_fullStr | Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation |
| title_full_unstemmed | Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation |
| title_short | Tenascin C in radiation‐induced lung damage: Pathological expression and serum level elevation |
| title_sort | tenascin c in radiation induced lung damage pathological expression and serum level elevation |
| topic | radiation fibrosis radiation induced lung damage radiation pneumonitis tenascin C |
| url | https://doi.org/10.1111/1759-7714.14624 |
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