Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study
Abstract Background Gliomas consist of a heterogeneous group of tumors. This study aimed to report the incidences of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, 1p19q co-deletion, isocitrate dehydrogenase (IDH) gene mutations, and inactivating mutations of alpha-thalassemia/m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-020-6536-x |
| _version_ | 1818642966163488768 |
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| author | Samantha Ya Lyn Ang Lester Lee Angela An Qi See Ting Yao Ang Beng Ti Ang Nicolas Kon Kam King |
| author_facet | Samantha Ya Lyn Ang Lester Lee Angela An Qi See Ting Yao Ang Beng Ti Ang Nicolas Kon Kam King |
| author_sort | Samantha Ya Lyn Ang |
| collection | DOAJ |
| description | Abstract Background Gliomas consist of a heterogeneous group of tumors. This study aimed to report the incidences of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, 1p19q co-deletion, isocitrate dehydrogenase (IDH) gene mutations, and inactivating mutations of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) in high-grade gliomas in an ethnically diverse population. Methods Records of patients who underwent surgery for high-grade gliomas from January 2013 to March 2017 at our institution were obtained. The patients’ age, gender, ethnicity, Karnofsky Performance Scale (KPS) score, ability to perform activities of daily living (ADLs), tumor location and biomarkers status were recorded. Data were analyzed using chi-square and Mann-Whitney U tests, Kaplan-Meier estimates and log-rank test. Results 181 patients were selected (56 with grade III gliomas, 125 with grade IV gliomas). In the grade III group, 55% had MGMT promoter methylation, 41% had 1p19q co-deletion, 35% had IDH1 mutation and none had ATRX loss. In the grade IV group, 30% had MGMT promoter methylation, 2% had 1p19q co-deletion, 15% had IDH1 mutation and 8% had ATRX loss. After adjusting for effects of age, surgery and pre-operative ADL statuses, only MGMT promoter methylation was found to be significantly associated with longer overall survival time in grade III (p = 0.024) and IV patients (p = 0.006). Conclusions The incidences of MGMT promoter methylation and IDH1 mutation were found to be comparable to globally reported rates, but those of 1p19q co-deletion and ATRX loss seemed to be lower in our cohort. MGMT promoter methylation was associated with increased overall survival in our cohort and might serve as favorable prognostic factor. |
| first_indexed | 2024-12-16T23:51:27Z |
| format | Article |
| id | doaj.art-7ecd7484c5054722b589ac766b32335e |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-16T23:51:27Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7ecd7484c5054722b589ac766b32335e2022-12-21T22:11:19ZengBMCBMC Cancer1471-24072020-01-012011910.1186/s12885-020-6536-xIncidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based studySamantha Ya Lyn Ang0Lester Lee1Angela An Qi See2Ting Yao Ang3Beng Ti Ang4Nicolas Kon Kam King5Department of Neurosurgery, National Neuroscience InstituteDepartment of Neurosurgery, National Neuroscience InstituteDepartment of Neurosurgery, National Neuroscience InstituteDepartment of Neurosurgery, National Neuroscience InstituteDepartment of Neurosurgery, National Neuroscience InstituteDepartment of Neurosurgery, National Neuroscience InstituteAbstract Background Gliomas consist of a heterogeneous group of tumors. This study aimed to report the incidences of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, 1p19q co-deletion, isocitrate dehydrogenase (IDH) gene mutations, and inactivating mutations of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) in high-grade gliomas in an ethnically diverse population. Methods Records of patients who underwent surgery for high-grade gliomas from January 2013 to March 2017 at our institution were obtained. The patients’ age, gender, ethnicity, Karnofsky Performance Scale (KPS) score, ability to perform activities of daily living (ADLs), tumor location and biomarkers status were recorded. Data were analyzed using chi-square and Mann-Whitney U tests, Kaplan-Meier estimates and log-rank test. Results 181 patients were selected (56 with grade III gliomas, 125 with grade IV gliomas). In the grade III group, 55% had MGMT promoter methylation, 41% had 1p19q co-deletion, 35% had IDH1 mutation and none had ATRX loss. In the grade IV group, 30% had MGMT promoter methylation, 2% had 1p19q co-deletion, 15% had IDH1 mutation and 8% had ATRX loss. After adjusting for effects of age, surgery and pre-operative ADL statuses, only MGMT promoter methylation was found to be significantly associated with longer overall survival time in grade III (p = 0.024) and IV patients (p = 0.006). Conclusions The incidences of MGMT promoter methylation and IDH1 mutation were found to be comparable to globally reported rates, but those of 1p19q co-deletion and ATRX loss seemed to be lower in our cohort. MGMT promoter methylation was associated with increased overall survival in our cohort and might serve as favorable prognostic factor.https://doi.org/10.1186/s12885-020-6536-xHigh-grade gliomaIncidenceMGMT1p19qIDHATRX |
| spellingShingle | Samantha Ya Lyn Ang Lester Lee Angela An Qi See Ting Yao Ang Beng Ti Ang Nicolas Kon Kam King Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study BMC Cancer High-grade glioma Incidence MGMT 1p19q IDH ATRX |
| title | Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study |
| title_full | Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study |
| title_fullStr | Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study |
| title_full_unstemmed | Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study |
| title_short | Incidence of biomarkers in high-grade gliomas and their impact on survival in a diverse SouthEast Asian cohort - a population-based study |
| title_sort | incidence of biomarkers in high grade gliomas and their impact on survival in a diverse southeast asian cohort a population based study |
| topic | High-grade glioma Incidence MGMT 1p19q IDH ATRX |
| url | https://doi.org/10.1186/s12885-020-6536-x |
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