Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease
Behcet’s disease (BD) is a chronic multi-systemic disease characterized by relapsing-remitting oral ulcers, genital ulcers, ocular inflammatory involvements, and numerous other systemic features. Ocular involvements are quite common in BD and may cause severe tissue damage and potentially blindness....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206959/full |
| _version_ | 1797670042804944896 |
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| author | Suibin Lin Zhirong Xu Zhiming Lin Baozhao Xie Junmei Feng Junmei Feng |
| author_facet | Suibin Lin Zhirong Xu Zhiming Lin Baozhao Xie Junmei Feng Junmei Feng |
| author_sort | Suibin Lin |
| collection | DOAJ |
| description | Behcet’s disease (BD) is a chronic multi-systemic disease characterized by relapsing-remitting oral ulcers, genital ulcers, ocular inflammatory involvements, and numerous other systemic features. Ocular involvements are quite common in BD and may cause severe tissue damage and potentially blindness. Even though the pathogenesis of BD remains ambiguous, growing evidences have shown that genetic factors, environmental triggers and immunological abnormalities play significant roles in its development and progression. Novel biotherapies targeting IFN-γ, TNF-α and interleukins have been used in recent years. In this review, we mainly pay attention to the ocular involvement of BD, and discuss the current understanding of mechanisms and advances in therapeutic approaches, especially novel biologics. Finally, we discuss the management in patients with pregnancy. |
| first_indexed | 2024-03-11T20:53:57Z |
| format | Article |
| id | doaj.art-7ecd74bd594f47de97e063bae90812aa |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T20:53:57Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7ecd74bd594f47de97e063bae90812aa2023-09-30T21:20:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12069591206959Advances in pathogenesis and treatment of ocular involvement in Behcet’s diseaseSuibin Lin0Zhirong Xu1Zhiming Lin2Baozhao Xie3Junmei Feng4Junmei Feng5Department of Gynaecology and Obstetrics, Zhangpu Hospital, Zhangzhou, ChinaDepartment of Internal Medicine, Zhangpu Hospital, Zhangzhou, ChinaDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, the Seventh Affiliated Hospital of Guangxi Medical University (Wuzhou Gongren Hospital), Wuzhou, ChinaDepartment of Rheumatology and Immunology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Rheumatology and Immunology, Nanfang Hospital of Southern Medical University, Guangzhou, ChinaBehcet’s disease (BD) is a chronic multi-systemic disease characterized by relapsing-remitting oral ulcers, genital ulcers, ocular inflammatory involvements, and numerous other systemic features. Ocular involvements are quite common in BD and may cause severe tissue damage and potentially blindness. Even though the pathogenesis of BD remains ambiguous, growing evidences have shown that genetic factors, environmental triggers and immunological abnormalities play significant roles in its development and progression. Novel biotherapies targeting IFN-γ, TNF-α and interleukins have been used in recent years. In this review, we mainly pay attention to the ocular involvement of BD, and discuss the current understanding of mechanisms and advances in therapeutic approaches, especially novel biologics. Finally, we discuss the management in patients with pregnancy.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206959/fullBehcet’s diseaseocular involvementBehcet’s uveitisimmunopathogenesisimmunogeneticbiological agent |
| spellingShingle | Suibin Lin Zhirong Xu Zhiming Lin Baozhao Xie Junmei Feng Junmei Feng Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease Frontiers in Immunology Behcet’s disease ocular involvement Behcet’s uveitis immunopathogenesis immunogenetic biological agent |
| title | Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease |
| title_full | Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease |
| title_fullStr | Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease |
| title_full_unstemmed | Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease |
| title_short | Advances in pathogenesis and treatment of ocular involvement in Behcet’s disease |
| title_sort | advances in pathogenesis and treatment of ocular involvement in behcet s disease |
| topic | Behcet’s disease ocular involvement Behcet’s uveitis immunopathogenesis immunogenetic biological agent |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206959/full |
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