Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc
The intervertebral disc (IVD) is a complex joint structure comprising three primary components—namely, nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP). The IVD retrieves oxygen from the surrounding vertebral body through CEP by diffusion and likely generates ATP via an...
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/10/5281 |
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| author | Jin-Woo Kim Neunghan Jeon Dong-Eun Shin So-Young Lee Myongwhan Kim Dong Hun Han Jae Yeon Shin Soonchul Lee |
| author_facet | Jin-Woo Kim Neunghan Jeon Dong-Eun Shin So-Young Lee Myongwhan Kim Dong Hun Han Jae Yeon Shin Soonchul Lee |
| author_sort | Jin-Woo Kim |
| collection | DOAJ |
| description | The intervertebral disc (IVD) is a complex joint structure comprising three primary components—namely, nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP). The IVD retrieves oxygen from the surrounding vertebral body through CEP by diffusion and likely generates ATP via anaerobic glycolysis. IVD degeneration is characterized by a cascade of cellular, compositional, structural changes. With advanced age, pronounced changes occur in the composition of the disc extracellular matrix (ECM). NP and AF cells in the IVD possess poor regenerative capacity compared with that of other tissues. Hypoxia-inducible factor (HIF) is a master transcription factor that initiates a coordinated cellular cascade in response to a low oxygen tension environment, including the regulation of numerous enzymes in response to hypoxia. HIF-1α is essential for NP development and homeostasis and is involved in various processes of IVD degeneration process, promotes ECM in NP, maintains the metabolic activities of NP, and regulates dystrophic mineralization of NP, as well as angiogenesis, autophagy, and apoptosis during IVD degeneration. HIF-1α may, therefore, represent a diagnostic tool for early IVD degeneration and a therapeutic target for inhibiting IVD degeneration |
| first_indexed | 2024-03-10T11:20:04Z |
| format | Article |
| id | doaj.art-7ed4f0ead03d48c59fe4e82bdc3d3b93 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:20:04Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7ed4f0ead03d48c59fe4e82bdc3d3b932023-11-21T20:08:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012210528110.3390/ijms22105281Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral DiscJin-Woo Kim0Neunghan Jeon1Dong-Eun Shin2So-Young Lee3Myongwhan Kim4Dong Hun Han5Jae Yeon Shin6Soonchul Lee7Department of Orthopaedic Surgery, Nowon Eulji Medical Center, Eulji University, Seoul 01830, KoreaDepartment of Orthopaedic Surgery, Nowon Eulji Medical Center, Eulji University, Seoul 01830, KoreaDepartment of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13488, KoreaDepartment of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si 13488, KoreaDepartment of Orthopaedic Surgery, Nowon Eulji Medical Center, Eulji University, Seoul 01830, KoreaDepartment of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13488, KoreaDepartment of Computer Science, College of IT Engineering, SeMyung University, Jechun 27136, KoreaDepartment of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam-si 13488, KoreaThe intervertebral disc (IVD) is a complex joint structure comprising three primary components—namely, nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP). The IVD retrieves oxygen from the surrounding vertebral body through CEP by diffusion and likely generates ATP via anaerobic glycolysis. IVD degeneration is characterized by a cascade of cellular, compositional, structural changes. With advanced age, pronounced changes occur in the composition of the disc extracellular matrix (ECM). NP and AF cells in the IVD possess poor regenerative capacity compared with that of other tissues. Hypoxia-inducible factor (HIF) is a master transcription factor that initiates a coordinated cellular cascade in response to a low oxygen tension environment, including the regulation of numerous enzymes in response to hypoxia. HIF-1α is essential for NP development and homeostasis and is involved in various processes of IVD degeneration process, promotes ECM in NP, maintains the metabolic activities of NP, and regulates dystrophic mineralization of NP, as well as angiogenesis, autophagy, and apoptosis during IVD degeneration. HIF-1α may, therefore, represent a diagnostic tool for early IVD degeneration and a therapeutic target for inhibiting IVD degenerationhttps://www.mdpi.com/1422-0067/22/10/5281hypoxia-inducible factor-1αregenerationintervertebral discdisc degenerationnucleus pulposus |
| spellingShingle | Jin-Woo Kim Neunghan Jeon Dong-Eun Shin So-Young Lee Myongwhan Kim Dong Hun Han Jae Yeon Shin Soonchul Lee Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc International Journal of Molecular Sciences hypoxia-inducible factor-1α regeneration intervertebral disc disc degeneration nucleus pulposus |
| title | Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc |
| title_full | Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc |
| title_fullStr | Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc |
| title_full_unstemmed | Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc |
| title_short | Regeneration in Spinal Disease: Therapeutic Role of Hypoxia-Inducible Factor-1 Alpha in Regeneration of Degenerative Intervertebral Disc |
| title_sort | regeneration in spinal disease therapeutic role of hypoxia inducible factor 1 alpha in regeneration of degenerative intervertebral disc |
| topic | hypoxia-inducible factor-1α regeneration intervertebral disc disc degeneration nucleus pulposus |
| url | https://www.mdpi.com/1422-0067/22/10/5281 |
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