Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020
Introduction: Quarantining is commonly used to mitigate the spread of SARS-CoV-2. However, questions remain regarding what specific interventions are most effective. Methods: After a 2-week home quarantine, U.S. Marine Corps recruits underwent a supervised 2-week quarantine at a hotel from August 11...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | AJPM Focus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773065422000025 |
| _version_ | 1797989306182139904 |
|---|---|
| author | Andrew G. Letizia, MD Carl W. Goforth, PhD Yongchao Ge, PhD Michael S. Termini, MD Megan A. Schilling, PhD Victor A. Sugiharto, PhD Hua Wei Chen, PhD Irene Ramos, PhD Stuart C. Sealfon, MD |
| author_facet | Andrew G. Letizia, MD Carl W. Goforth, PhD Yongchao Ge, PhD Michael S. Termini, MD Megan A. Schilling, PhD Victor A. Sugiharto, PhD Hua Wei Chen, PhD Irene Ramos, PhD Stuart C. Sealfon, MD |
| author_sort | Andrew G. Letizia, MD |
| collection | DOAJ |
| description | Introduction: Quarantining is commonly used to mitigate the spread of SARS-CoV-2. However, questions remain regarding what specific interventions are most effective. Methods: After a 2-week home quarantine, U.S. Marine Corps recruits underwent a supervised 2-week quarantine at a hotel from August 11 to September 21, 2020. All recruits were assessed for symptoms through oral questioning and had their temperatures checked daily. Study participants answered a written clinical questionnaire and were tested for SARS-CoV-2 by polymerase chain reaction shortly after arrival in quarantine and on Days 7 and 14. The results were compared with those of a previously reported Marine-supervised quarantine at a college campus from May until July 2020 utilizing the same study, laboratory, and statistical procedures. Results: A total of 1,401 of 1,514 eligible recruits (92.5%) enrolled in the study, 93.1% of whom were male. At the time of enrollment, 12 of 1,401 (0.9%) participants were polymerase chain reaction positive for SARS-CoV-2, 9 of 1,376 (0.7%) were positive on Day 7, and 1 of 1,358 (0.1%) was positive on Day 14. Only 12 of 22 (54.5%) participants endorsed any symptoms on a study questionnaire, and none of the participants had an elevated temperature or endorsed symptoms during daily screening for SARS-CoV-2. Participation rate (92%) was much greater than the approximately 58.8% (1,848 of 3,143) rate observed in the previous Marine-supervised college campus quarantine, suggesting the changing attitudes of recruits during the pandemic (p<0.001). Approximately 1% of participants were quantitative polymerase chain reaction positive after self-quarantine in both studies. Conclusions: Key findings include the shifting attitudes of young adults during the pandemic, the limitations of self-quarantine, and the ineffectiveness of daily temperature and symptom screening to identify SARS-CoV-2‒positive recruits. |
| first_indexed | 2024-04-11T08:18:12Z |
| format | Article |
| id | doaj.art-7ed58ca26f554b50a6fd7bb5cfdbc936 |
| institution | Directory Open Access Journal |
| issn | 2773-0654 |
| language | English |
| last_indexed | 2024-04-11T08:18:12Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJPM Focus |
| spelling | doaj.art-7ed58ca26f554b50a6fd7bb5cfdbc9362022-12-22T04:35:04ZengElsevierAJPM Focus2773-06542022-09-0111100003Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020Andrew G. Letizia, MD0Carl W. Goforth, PhD1Yongchao Ge, PhD2Michael S. Termini, MD3Megan A. Schilling, PhD4Victor A. Sugiharto, PhD5Hua Wei Chen, PhD6Irene Ramos, PhD7Stuart C. Sealfon, MD8Naval Medical Research Center, Navy Medicine, Silver Spring, Maryland; Address correspondence to: Andrew G. Letizia, Naval Medical Research Center-Asia, 503 Robert Grant Avenue, Silver Spring MD 20910.Naval Medical Research Center, Navy Medicine, Silver Spring, MarylandDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New YorkNavy Medicine Readiness and Training Command Beaufort, Navy Medicine, Beaufort, South CarolinaNaval Medical Research Center, Navy Medicine, Silver Spring, MarylandNaval Medical Research Center, Navy Medicine, Silver Spring, Maryland; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MarylandNaval Medical Research Center, Navy Medicine, Silver Spring, Maryland; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MarylandDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New YorkDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New YorkIntroduction: Quarantining is commonly used to mitigate the spread of SARS-CoV-2. However, questions remain regarding what specific interventions are most effective. Methods: After a 2-week home quarantine, U.S. Marine Corps recruits underwent a supervised 2-week quarantine at a hotel from August 11 to September 21, 2020. All recruits were assessed for symptoms through oral questioning and had their temperatures checked daily. Study participants answered a written clinical questionnaire and were tested for SARS-CoV-2 by polymerase chain reaction shortly after arrival in quarantine and on Days 7 and 14. The results were compared with those of a previously reported Marine-supervised quarantine at a college campus from May until July 2020 utilizing the same study, laboratory, and statistical procedures. Results: A total of 1,401 of 1,514 eligible recruits (92.5%) enrolled in the study, 93.1% of whom were male. At the time of enrollment, 12 of 1,401 (0.9%) participants were polymerase chain reaction positive for SARS-CoV-2, 9 of 1,376 (0.7%) were positive on Day 7, and 1 of 1,358 (0.1%) was positive on Day 14. Only 12 of 22 (54.5%) participants endorsed any symptoms on a study questionnaire, and none of the participants had an elevated temperature or endorsed symptoms during daily screening for SARS-CoV-2. Participation rate (92%) was much greater than the approximately 58.8% (1,848 of 3,143) rate observed in the previous Marine-supervised college campus quarantine, suggesting the changing attitudes of recruits during the pandemic (p<0.001). Approximately 1% of participants were quantitative polymerase chain reaction positive after self-quarantine in both studies. Conclusions: Key findings include the shifting attitudes of young adults during the pandemic, the limitations of self-quarantine, and the ineffectiveness of daily temperature and symptom screening to identify SARS-CoV-2‒positive recruits.http://www.sciencedirect.com/science/article/pii/S2773065422000025QuarantineSARS-CoV-2 screeningtemperature screeningrecruitsyoung adultsSARS-CoV-2 modeling |
| spellingShingle | Andrew G. Letizia, MD Carl W. Goforth, PhD Yongchao Ge, PhD Michael S. Termini, MD Megan A. Schilling, PhD Victor A. Sugiharto, PhD Hua Wei Chen, PhD Irene Ramos, PhD Stuart C. Sealfon, MD Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020 AJPM Focus Quarantine SARS-CoV-2 screening temperature screening recruits young adults SARS-CoV-2 modeling |
| title | Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020 |
| title_full | Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020 |
| title_fullStr | Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020 |
| title_full_unstemmed | Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020 |
| title_short | Lessons Learned From a Prospective Observational Study of U.S. Marine Recruits During a Supervised Quarantine, Spring‒Fall 2020 |
| title_sort | lessons learned from a prospective observational study of u s marine recruits during a supervised quarantine spring fall 2020 |
| topic | Quarantine SARS-CoV-2 screening temperature screening recruits young adults SARS-CoV-2 modeling |
| url | http://www.sciencedirect.com/science/article/pii/S2773065422000025 |
| work_keys_str_mv | AT andrewgletiziamd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT carlwgoforthphd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT yongchaogephd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT michaelsterminimd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT meganaschillingphd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT victorasugihartophd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT huaweichenphd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT ireneramosphd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 AT stuartcsealfonmd lessonslearnedfromaprospectiveobservationalstudyofusmarinerecruitsduringasupervisedquarantinespringfall2020 |