Upstream deregulation of calcium signalling in Parkinson´s disease
Parkinson´s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handlin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-06-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00053/full |
| _version_ | 1819020258298560512 |
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| author | Pilar eRivero-Ríos Patricia eGómez-Suaga Elena eFdez Sabine eHilfiker |
| author_facet | Pilar eRivero-Ríos Patricia eGómez-Suaga Elena eFdez Sabine eHilfiker |
| author_sort | Pilar eRivero-Ríos |
| collection | DOAJ |
| description | Parkinson´s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression. |
| first_indexed | 2024-12-21T03:48:21Z |
| format | Article |
| id | doaj.art-7ed5dab377584750b68403c5a5006f1c |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-21T03:48:21Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-7ed5dab377584750b68403c5a5006f1c2022-12-21T19:17:01ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992014-06-01710.3389/fnmol.2014.0005398502Upstream deregulation of calcium signalling in Parkinson´s diseasePilar eRivero-Ríos0Patricia eGómez-Suaga1Elena eFdez2Sabine eHilfiker3Consejo Superior de Investigaciones Científicas (CSIC)Consejo Superior de Investigaciones Científicas (CSIC)Consejo Superior de Investigaciones Científicas (CSIC)Consejo Superior de Investigaciones Científicas (CSIC)Parkinson´s disease (PD) is a major health problem affecting millions of people worldwide. Recent studies provide compelling evidence that altered Ca2+ homeostasis may underlie disease pathomechanism and be an inherent feature of all vulnerable neurons. The downstream effects of altered Ca2+ handling in the distinct subcellular organelles for proper cellular function are beginning to be elucidated. Here, we summarize the evidence that vulnerable neurons may be exposed to homeostatic Ca2+ stress which may determine their selective vulnerability, and suggest how abnormal Ca2+ handling in the distinct intracellular compartments may compromise neuronal health in the context of aging, environmental and genetic stress. Gaining a better understanding of the varied effects of Ca2+ dyshomeostasis may allow novel combinatorial therapeutic strategies to slow PD progression.http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00053/fullCalciumDopamineEndoplasmic ReticulumMitochondriaGolgiOxidant Stress |
| spellingShingle | Pilar eRivero-Ríos Patricia eGómez-Suaga Elena eFdez Sabine eHilfiker Upstream deregulation of calcium signalling in Parkinson´s disease Frontiers in Molecular Neuroscience Calcium Dopamine Endoplasmic Reticulum Mitochondria Golgi Oxidant Stress |
| title | Upstream deregulation of calcium signalling in Parkinson´s disease |
| title_full | Upstream deregulation of calcium signalling in Parkinson´s disease |
| title_fullStr | Upstream deregulation of calcium signalling in Parkinson´s disease |
| title_full_unstemmed | Upstream deregulation of calcium signalling in Parkinson´s disease |
| title_short | Upstream deregulation of calcium signalling in Parkinson´s disease |
| title_sort | upstream deregulation of calcium signalling in parkinson 180 s disease |
| topic | Calcium Dopamine Endoplasmic Reticulum Mitochondria Golgi Oxidant Stress |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00053/full |
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