Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus

INTRODUCTION[|]The aim of this study was to assess initial changes in blood flow parameters of the ophthalmic artery (OA) in pediatric patients with type 1 diabetes mellitus (DM).[¤]METHODS[|]Sixty-three subjects were included in this prospective, cross-sectional, observational study. Thirty-one (49...

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Main Authors: Serdar Ozates, Betul Emine Derinkuyu, Ufuk Elgin, Meliksah Keskin, Nursel Muratoglu Sahin, Zehra Aycan
Format: Article
Language:English
Published: KARE Publishing 2020-02-01
Series:Beyoglu Eye Journal
Subjects:
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=beyoglu&un=BEJ-15238
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author Serdar Ozates
Betul Emine Derinkuyu
Ufuk Elgin
Meliksah Keskin
Nursel Muratoglu Sahin
Zehra Aycan
author_facet Serdar Ozates
Betul Emine Derinkuyu
Ufuk Elgin
Meliksah Keskin
Nursel Muratoglu Sahin
Zehra Aycan
author_sort Serdar Ozates
collection DOAJ
description INTRODUCTION[|]The aim of this study was to assess initial changes in blood flow parameters of the ophthalmic artery (OA) in pediatric patients with type 1 diabetes mellitus (DM).[¤]METHODS[|]Sixty-three subjects were included in this prospective, cross-sectional, observational study. Thirty-one (49.2%) patients with type 1 DM without diabetic retinopathy formed the DM group. The control group comprised 32 (50.8%) healthy subjects. The OA of all of the patients was examined with Doppler ultrasonography. The main outcomes were peak systolic velocity (PSV), end diastolic velocity (EDV), pulsatility index (PI), and resistivity index (RI) measurements.[¤]RESULTS[|]The mean age at onset of type 1 DM was 10.7+-2.0 years and the mean duration was 11.4+-11.0 months. The mean PSV and EDV outcomes in both eyes were significantly higher in the control group than in the DM group, whereas, the mean PI and RI outcomes in both eyes were significantly higher in the DM group (p<0.05). A mean RI of ≥0.75 indicated vascular hemodynamic changes associated with type 1 DM with a sensitivity of 72% and a specificity of 65% (area under the curve: 0.702; p=0.007). A mean PI of ≥1.69 predicted vascular hemodynamic changes associated with type 1 DM with a sensitivity of 79% and a specificity of 71% (area under the curve: 0.742; p=0.001).[¤]DISCUSSION AND CONCLUSION[|]The results of this study revealed that disturbances in ocular hemodynamics might be present as early as the first year after a type 1 DM diagnosis. Changes in ocular hemodynamic parameters could be used to predict or screen for the development of vascular changes.[¤]
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spelling doaj.art-7ed5f71adefa40cb9fdaf51ac9350ee02023-02-15T16:12:00ZengKARE PublishingBeyoglu Eye Journal2587-03942020-02-0151172110.14744/bej.2020.15238BEJ-15238Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes MellitusSerdar Ozates0Betul Emine Derinkuyu1Ufuk Elgin2Meliksah Keskin3Nursel Muratoglu Sahin4Zehra Aycan5Department of Ophthalmology, Kars Harakani State Hospital, Kars, TurkeyDepartment of Radiology, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, Ankara, TurkeyDepartment of Ophthalmology, Ulucanlar Eye Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, Ankara, TurkeyDepartment of Endocrinology, Dr. Sami Ulus Maternity, Children's Health and Diseases Training and Research Hospital, Ankara, TurkeyINTRODUCTION[|]The aim of this study was to assess initial changes in blood flow parameters of the ophthalmic artery (OA) in pediatric patients with type 1 diabetes mellitus (DM).[¤]METHODS[|]Sixty-three subjects were included in this prospective, cross-sectional, observational study. Thirty-one (49.2%) patients with type 1 DM without diabetic retinopathy formed the DM group. The control group comprised 32 (50.8%) healthy subjects. The OA of all of the patients was examined with Doppler ultrasonography. The main outcomes were peak systolic velocity (PSV), end diastolic velocity (EDV), pulsatility index (PI), and resistivity index (RI) measurements.[¤]RESULTS[|]The mean age at onset of type 1 DM was 10.7+-2.0 years and the mean duration was 11.4+-11.0 months. The mean PSV and EDV outcomes in both eyes were significantly higher in the control group than in the DM group, whereas, the mean PI and RI outcomes in both eyes were significantly higher in the DM group (p<0.05). A mean RI of ≥0.75 indicated vascular hemodynamic changes associated with type 1 DM with a sensitivity of 72% and a specificity of 65% (area under the curve: 0.702; p=0.007). A mean PI of ≥1.69 predicted vascular hemodynamic changes associated with type 1 DM with a sensitivity of 79% and a specificity of 71% (area under the curve: 0.742; p=0.001).[¤]DISCUSSION AND CONCLUSION[|]The results of this study revealed that disturbances in ocular hemodynamics might be present as early as the first year after a type 1 DM diagnosis. Changes in ocular hemodynamic parameters could be used to predict or screen for the development of vascular changes.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=beyoglu&un=BEJ-15238arterial resistanceblood flowdoppler sonographyophthalmic arterytype 1 diabetes mellitus.
spellingShingle Serdar Ozates
Betul Emine Derinkuyu
Ufuk Elgin
Meliksah Keskin
Nursel Muratoglu Sahin
Zehra Aycan
Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus
Beyoglu Eye Journal
arterial resistance
blood flow
doppler sonography
ophthalmic artery
type 1 diabetes mellitus.
title Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus
title_full Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus
title_fullStr Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus
title_full_unstemmed Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus
title_short Early Ophthalmic Artery Blood Flow Parameter Changes in Patients with Type 1 Diabetes Mellitus
title_sort early ophthalmic artery blood flow parameter changes in patients with type 1 diabetes mellitus
topic arterial resistance
blood flow
doppler sonography
ophthalmic artery
type 1 diabetes mellitus.
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=beyoglu&un=BEJ-15238
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