Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series
Introduction: Severe acute respiratory syndrome coronavirus-2 infection mostly involves pediatrics lesser than adults; however, the multisystem inflammatory syndrome in children is shown to be the following condition in children infected with SARS-CoV-2, even asymptomatic ones. To date, there is few...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023057742 |
| _version_ | 1797733003147870208 |
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| author | Amin Dehghan Rana Saleh Hamid Rahimi Zahra Pourmoghaddas Atefeh Sadeghizadeh Niloofar Javadi |
| author_facet | Amin Dehghan Rana Saleh Hamid Rahimi Zahra Pourmoghaddas Atefeh Sadeghizadeh Niloofar Javadi |
| author_sort | Amin Dehghan |
| collection | DOAJ |
| description | Introduction: Severe acute respiratory syndrome coronavirus-2 infection mostly involves pediatrics lesser than adults; however, the multisystem inflammatory syndrome in children is shown to be the following condition in children infected with SARS-CoV-2, even asymptomatic ones. To date, there is few evidence of the association of multisystem inflammatory syndrome in children with acute neurological symptoms. Case presentations: This case series was recorded demographic, clinical, laboratory, radiographic and EEG data of patients with the multisystem inflammatory syndrome in children who diagnosed simultaneously with acute neurological symptoms. Children with the multisystem inflammatory syndrome in children and evidence of central nervous system involvements participated in the study. Data are reported as median (interquartile ranges) for quantitative data without normal distributions. The present study was conducted at the children's referral hospital of Isfahan province, Iran between March 1, 2020, and December 28, 2021. Simultaneous diagnosis of multisystem inflammatory syndrome in children and acute neurological symptoms was made in 12 children. The median age of patients was 4.5 years (10–144 months). The most common symptoms were seizures (58%). Cerebrospinal fluid analysis showed that only one patient had pleocytosis. In addition, one patient had a low glucose level. Finally, 11 patients were discharged in good condition and one patient died after full recovery from acute neurological symptoms due to her underlying disease. Conclusion: According to our series and other studies, children with MIS-C may present signs and symptoms of acute neurological symptoms. Although its pathophysiology is unclear, studies showed that immunomodulatory agents, i.e., intravenous immunoglobulins and corticosteroids, provide a relatively good prognosis. |
| first_indexed | 2024-03-12T12:22:40Z |
| format | Article |
| id | doaj.art-7ed736efe1664ba08b8d9d6d6fe9abbe |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:22:40Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7ed736efe1664ba08b8d9d6d6fe9abbe2023-08-30T05:51:46ZengElsevierHeliyon2405-84402023-08-0198e18566Acute neurological symptoms in multisystem inflammatory syndrome in children: A case seriesAmin Dehghan0Rana Saleh1Hamid Rahimi2Zahra Pourmoghaddas3Atefeh Sadeghizadeh4Niloofar Javadi5Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranPediatrics Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranPediatric Infectious Diseases Department, Isfahan University of Medical Sciences, Isfahan, IranPediatric Infectious Diseases Department, Isfahan University of Medical Sciences, Isfahan, IranPediatric Intensive Cares Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Corresponding author. Pediatric Infectious Disease Department, Imam Hossein Hospital, Imam Khomeini St, Isfahan, Iran.Introduction: Severe acute respiratory syndrome coronavirus-2 infection mostly involves pediatrics lesser than adults; however, the multisystem inflammatory syndrome in children is shown to be the following condition in children infected with SARS-CoV-2, even asymptomatic ones. To date, there is few evidence of the association of multisystem inflammatory syndrome in children with acute neurological symptoms. Case presentations: This case series was recorded demographic, clinical, laboratory, radiographic and EEG data of patients with the multisystem inflammatory syndrome in children who diagnosed simultaneously with acute neurological symptoms. Children with the multisystem inflammatory syndrome in children and evidence of central nervous system involvements participated in the study. Data are reported as median (interquartile ranges) for quantitative data without normal distributions. The present study was conducted at the children's referral hospital of Isfahan province, Iran between March 1, 2020, and December 28, 2021. Simultaneous diagnosis of multisystem inflammatory syndrome in children and acute neurological symptoms was made in 12 children. The median age of patients was 4.5 years (10–144 months). The most common symptoms were seizures (58%). Cerebrospinal fluid analysis showed that only one patient had pleocytosis. In addition, one patient had a low glucose level. Finally, 11 patients were discharged in good condition and one patient died after full recovery from acute neurological symptoms due to her underlying disease. Conclusion: According to our series and other studies, children with MIS-C may present signs and symptoms of acute neurological symptoms. Although its pathophysiology is unclear, studies showed that immunomodulatory agents, i.e., intravenous immunoglobulins and corticosteroids, provide a relatively good prognosis.http://www.sciencedirect.com/science/article/pii/S2405844023057742Multisystem inflammatory syndrome in childrenCentral nervous systemAcute neurological symptoms |
| spellingShingle | Amin Dehghan Rana Saleh Hamid Rahimi Zahra Pourmoghaddas Atefeh Sadeghizadeh Niloofar Javadi Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series Heliyon Multisystem inflammatory syndrome in children Central nervous system Acute neurological symptoms |
| title | Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series |
| title_full | Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series |
| title_fullStr | Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series |
| title_full_unstemmed | Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series |
| title_short | Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series |
| title_sort | acute neurological symptoms in multisystem inflammatory syndrome in children a case series |
| topic | Multisystem inflammatory syndrome in children Central nervous system Acute neurological symptoms |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023057742 |
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