Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin
The interaction of the antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin was investigated by methods of optical spectroscopy. Established that HP-beta-CD binds specifically to EMAP II. The most likely binding site is partially exposed residue Trp126, localized in depressions on the sur...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taras Shevchenko National University of Kyiv
2016-08-01
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| Series: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| Subjects: | |
| Online Access: | http://biovestnik.com/index.php/biology/article/view/107 |
| _version_ | 1797714903044194304 |
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| author | A. Malyna O. Kornelyuk |
| author_facet | A. Malyna O. Kornelyuk |
| author_sort | A. Malyna |
| collection | DOAJ |
| description | The interaction of the antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin was investigated by methods of optical spectroscopy. Established that HP-beta-CD binds specifically to EMAP II. The most likely binding site is partially exposed residue Trp126, localized in depressions on the surface of EMAP II along with functionally important lysine-rich cluster. |
| first_indexed | 2024-03-12T07:58:55Z |
| format | Article |
| id | doaj.art-7ed86568013d4012a2b5b7655436c186 |
| institution | Directory Open Access Journal |
| issn | 1728-2748 2308-8036 |
| language | English |
| last_indexed | 2024-03-12T07:58:55Z |
| publishDate | 2016-08-01 |
| publisher | Taras Shevchenko National University of Kyiv |
| record_format | Article |
| series | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| spelling | doaj.art-7ed86568013d4012a2b5b7655436c1862023-09-02T20:02:58ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362016-08-01691252898Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrinA. Malyna0O. Kornelyuk1Institute of Molecular Biology and Genetics of NASU, Kyiv1 - Institute of Molecular Biology and Genetics of NASU, Kyiv 2 - Taras Shevchenko National University of Kyiv, KyivThe interaction of the antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin was investigated by methods of optical spectroscopy. Established that HP-beta-CD binds specifically to EMAP II. The most likely binding site is partially exposed residue Trp126, localized in depressions on the surface of EMAP II along with functionally important lysine-rich cluster.http://biovestnik.com/index.php/biology/article/view/107fluorescence, hydroxypropyl-beta-cyclodextrin, recombinant cytokine EMAP II |
| spellingShingle | A. Malyna O. Kornelyuk Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ fluorescence, hydroxypropyl-beta-cyclodextrin, recombinant cytokine EMAP II |
| title | Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin |
| title_full | Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin |
| title_fullStr | Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin |
| title_full_unstemmed | Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin |
| title_short | Interaction of antitumor cytokine EMAP II with hydroxypropyl-beta-cyclodextrin |
| title_sort | interaction of antitumor cytokine emap ii with hydroxypropyl beta cyclodextrin |
| topic | fluorescence, hydroxypropyl-beta-cyclodextrin, recombinant cytokine EMAP II |
| url | http://biovestnik.com/index.php/biology/article/view/107 |
| work_keys_str_mv | AT amalyna interactionofantitumorcytokineemapiiwithhydroxypropylbetacyclodextrin AT okornelyuk interactionofantitumorcytokineemapiiwithhydroxypropylbetacyclodextrin |