Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial
Ramosetron, often used to prevent postoperative nausea and vomiting, might cause heart-rate-corrected (QTc) interval prolongation, as might robot-assisted laparoscopic prostatectomy (RALP), which requires a steep Trendelenburg position and CO<sub>2</sub> pneumoperitoneum. This study aime...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/12/5/811 |
| _version_ | 1797498609158062080 |
|---|---|
| author | Bora Lee So Yeon Kim Seung Hyun Kim Hyukjin Yang Jeong Hyun Jin Seung Ho Choi |
| author_facet | Bora Lee So Yeon Kim Seung Hyun Kim Hyukjin Yang Jeong Hyun Jin Seung Ho Choi |
| author_sort | Bora Lee |
| collection | DOAJ |
| description | Ramosetron, often used to prevent postoperative nausea and vomiting, might cause heart-rate-corrected (QTc) interval prolongation, as might robot-assisted laparoscopic prostatectomy (RALP), which requires a steep Trendelenburg position and CO<sub>2</sub> pneumoperitoneum. This study aimed to determine how ramosetron administration affects the QTc interval in patients treated with RALP. Fifty-six subjects were randomly assigned to ramosetron (n = 28) or control (n = 28) groups. The ramosetron group received 0.3 mg of ramosetron after anesthetic induction, whereas the control group received normal saline. The QTc interval was measured before and after induction; after 5, 30, and 60 min of being placed in the Trendelenburg position; immediately after being returned to a supine position; and at the end of surgery. Linear mixed models were used to compare QT intervals between groups. QTc intervals did not differ significantly between groups over time (P<sub>group×time</sub> = 0.111). However, they increased significantly in both groups after placement in the Trendelenburg position compared with before induction (P<sub>time</sub> < 0.001). This increase in QTc continued until the end of surgery in both groups. Based on these findings, ramosetron can be safely administered for the prevention of postoperative nausea and vomiting among patients undergoing RALP. |
| first_indexed | 2024-03-10T03:35:47Z |
| format | Article |
| id | doaj.art-7ed8af5e276b48b9976ea0635ec589f4 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T03:35:47Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-7ed8af5e276b48b9976ea0635ec589f42023-11-23T11:45:10ZengMDPI AGJournal of Personalized Medicine2075-44262022-05-0112581110.3390/jpm12050811Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized TrialBora Lee0So Yeon Kim1Seung Hyun Kim2Hyukjin Yang3Jeong Hyun Jin4Seung Ho Choi5Department of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaDepartment of Anesthesiology and Pain Medicine, Severance Hospital, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, KoreaRamosetron, often used to prevent postoperative nausea and vomiting, might cause heart-rate-corrected (QTc) interval prolongation, as might robot-assisted laparoscopic prostatectomy (RALP), which requires a steep Trendelenburg position and CO<sub>2</sub> pneumoperitoneum. This study aimed to determine how ramosetron administration affects the QTc interval in patients treated with RALP. Fifty-six subjects were randomly assigned to ramosetron (n = 28) or control (n = 28) groups. The ramosetron group received 0.3 mg of ramosetron after anesthetic induction, whereas the control group received normal saline. The QTc interval was measured before and after induction; after 5, 30, and 60 min of being placed in the Trendelenburg position; immediately after being returned to a supine position; and at the end of surgery. Linear mixed models were used to compare QT intervals between groups. QTc intervals did not differ significantly between groups over time (P<sub>group×time</sub> = 0.111). However, they increased significantly in both groups after placement in the Trendelenburg position compared with before induction (P<sub>time</sub> < 0.001). This increase in QTc continued until the end of surgery in both groups. Based on these findings, ramosetron can be safely administered for the prevention of postoperative nausea and vomiting among patients undergoing RALP.https://www.mdpi.com/2075-4426/12/5/811QTc prolongationramosetronrobot-assisted laparoscopic radical prostatectomyTrendelenburg |
| spellingShingle | Bora Lee So Yeon Kim Seung Hyun Kim Hyukjin Yang Jeong Hyun Jin Seung Ho Choi Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial Journal of Personalized Medicine QTc prolongation ramosetron robot-assisted laparoscopic radical prostatectomy Trendelenburg |
| title | Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial |
| title_full | Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial |
| title_fullStr | Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial |
| title_full_unstemmed | Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial |
| title_short | Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial |
| title_sort | heart rate corrected qt interval response to ramosetron during robot assisted laparoscopic prostatectomy a randomized trial |
| topic | QTc prolongation ramosetron robot-assisted laparoscopic radical prostatectomy Trendelenburg |
| url | https://www.mdpi.com/2075-4426/12/5/811 |
| work_keys_str_mv | AT boralee heartratecorrectedqtintervalresponsetoramosetronduringrobotassistedlaparoscopicprostatectomyarandomizedtrial AT soyeonkim heartratecorrectedqtintervalresponsetoramosetronduringrobotassistedlaparoscopicprostatectomyarandomizedtrial AT seunghyunkim heartratecorrectedqtintervalresponsetoramosetronduringrobotassistedlaparoscopicprostatectomyarandomizedtrial AT hyukjinyang heartratecorrectedqtintervalresponsetoramosetronduringrobotassistedlaparoscopicprostatectomyarandomizedtrial AT jeonghyunjin heartratecorrectedqtintervalresponsetoramosetronduringrobotassistedlaparoscopicprostatectomyarandomizedtrial AT seunghochoi heartratecorrectedqtintervalresponsetoramosetronduringrobotassistedlaparoscopicprostatectomyarandomizedtrial |