Worse Physical Disability Is Associated With the Expression of PD-1 on Inflammatory T-Cells in Multiple Sclerosis Patients With Older Appearing Brains

Worse Physical Disability Is Associated With the Expression of PD-1 on Inflammatory T-Cells in Multiple Sclerosis Patients With Older Appearing Brains

Background: Magnetic Resonance Imaging (MRI) analysis method “brain-age” paradigm could offer an intuitive prognostic metric (brain-predicted age difference: brain-PAD) for disability in Multiple Sclerosis (MS), reflecting structural brain health adjusted for aging. Equally, cellular senescence has...

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Bibliographic Details
Main Authors: Sophie A. H. Jacobs, Paolo A. Muraro, Maria T. Cencioni, Sarah Knowles, James H. Cole, Richard Nicholas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Neurology
Subjects:
multiple sclerosis
brain age
biomarkers
immunology
MRI
atrophy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.801097/full

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