Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction

Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction

Introduction: Primary mitochondrial diseases (PMD) are a large, heterogeneous group of genetic disorders affecting mitochondrial function, mostly by disrupting the oxidative phosphorylation (OXPHOS) system. Understanding the cellular metabolic re-wiring occurring in PMD is crucial for the developmen...

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Bibliographic Details
Main Authors: Isabelle Adant, Matthew Bird, Bram Decru, Petra Windmolders, Marie Wallays, Peter de Witte, Daisy Rymen, Peter Witters, Pieter Vermeersch, David Cassiman, Bart Ghesquière
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Metabolism
Subjects:
Primary mitochondrial disease
OXPHOS
Aspartic acid
Treatment
Pyruvate and uridine
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001065

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