Numerical Simulation of the Production of Core-Shell Microparticles
Conventional methods that are commonly used for the preparation of microbubble delivery systems include sonication, high-shear emulsification, and membrane emulsification. However, these methods present significant disadvantages, namely, poor control over the particle size and distribution. To date...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Londrina
2023-04-01
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| Series: | Semina: Ciências Exatas e Tecnológicas |
| Subjects: | |
| Online Access: | https://ojs.uel.br/revistas/uel/index.php/semexatas/article/view/47206 |
| _version_ | 1797837376660176896 |
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| author | Célio Fernandes Luis L. Ferrás Alexandre M. Afonso |
| author_facet | Célio Fernandes Luis L. Ferrás Alexandre M. Afonso |
| author_sort | Célio Fernandes |
| collection | DOAJ |
| description |
Conventional methods that are commonly used for the preparation of microbubble delivery systems include sonication, high-shear emulsification, and membrane emulsification. However, these methods present significant disadvantages, namely, poor control over the particle size and distribution. To date, engineering core-shell microparticles remains a challenging task. Thus, there is a demand for new techniques that can enable control over the size, composition, stability, and uniformity of microparticles. Microfluidic techniques offer great advantages in the fabrication of microparticles over the conventional processes because they require mild and inert processing conditions. In this work, we present a numerical study based on the finite volume method, for the development of capsules by considering the rheological properties of three phases, air, a perfluorohexane (C6 F14) and a polymeric solution constituted of a solution of 0.25% w/v alginate. This methodology allows studying the stability and behavior of microparticles under different processing conditions.
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| first_indexed | 2024-04-09T15:24:53Z |
| format | Article |
| id | doaj.art-7ed961162cef4f9781adab956407c29e |
| institution | Directory Open Access Journal |
| issn | 1676-5451 1679-0375 |
| language | English |
| last_indexed | 2024-04-09T15:24:53Z |
| publishDate | 2023-04-01 |
| publisher | Universidade Estadual de Londrina |
| record_format | Article |
| series | Semina: Ciências Exatas e Tecnológicas |
| spelling | doaj.art-7ed961162cef4f9781adab956407c29e2023-04-28T20:51:30ZengUniversidade Estadual de LondrinaSemina: Ciências Exatas e Tecnológicas1676-54511679-03752023-04-014410.5433/1679-0375.2023.v44.47206Numerical Simulation of the Production of Core-Shell MicroparticlesCélio Fernandes0Luis L. Ferrás1Alexandre M. Afonso2Polymer Engineering Department, University of Minho, Guimarães, PortugalCenter of Mathematics, University of Minho, Guimarães, PortugalCEFT, Faculty of Engineering, University of Porto, Porto, Portugal Conventional methods that are commonly used for the preparation of microbubble delivery systems include sonication, high-shear emulsification, and membrane emulsification. However, these methods present significant disadvantages, namely, poor control over the particle size and distribution. To date, engineering core-shell microparticles remains a challenging task. Thus, there is a demand for new techniques that can enable control over the size, composition, stability, and uniformity of microparticles. Microfluidic techniques offer great advantages in the fabrication of microparticles over the conventional processes because they require mild and inert processing conditions. In this work, we present a numerical study based on the finite volume method, for the development of capsules by considering the rheological properties of three phases, air, a perfluorohexane (C6 F14) and a polymeric solution constituted of a solution of 0.25% w/v alginate. This methodology allows studying the stability and behavior of microparticles under different processing conditions. https://ojs.uel.br/revistas/uel/index.php/semexatas/article/view/47206numerical methodsnumerical simulationfinite volume methodfree-surfacecore-shell particles |
| spellingShingle | Célio Fernandes Luis L. Ferrás Alexandre M. Afonso Numerical Simulation of the Production of Core-Shell Microparticles Semina: Ciências Exatas e Tecnológicas numerical methods numerical simulation finite volume method free-surface core-shell particles |
| title | Numerical Simulation of the Production of Core-Shell Microparticles |
| title_full | Numerical Simulation of the Production of Core-Shell Microparticles |
| title_fullStr | Numerical Simulation of the Production of Core-Shell Microparticles |
| title_full_unstemmed | Numerical Simulation of the Production of Core-Shell Microparticles |
| title_short | Numerical Simulation of the Production of Core-Shell Microparticles |
| title_sort | numerical simulation of the production of core shell microparticles |
| topic | numerical methods numerical simulation finite volume method free-surface core-shell particles |
| url | https://ojs.uel.br/revistas/uel/index.php/semexatas/article/view/47206 |
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