Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier
Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2513 |
| _version_ | 1797515012289331200 |
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| author | Ruiyi Zhang Mengzhou Xue Voon Wee Yong |
| author_facet | Ruiyi Zhang Mengzhou Xue Voon Wee Yong |
| author_sort | Ruiyi Zhang |
| collection | DOAJ |
| description | Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH. |
| first_indexed | 2024-03-10T06:40:32Z |
| format | Article |
| id | doaj.art-7ed9ca3660334e9aa736521f6382ff4f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:40:32Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7ed9ca3660334e9aa736521f6382ff4f2023-11-22T17:44:51ZengMDPI AGCells2073-44092021-09-011010251310.3390/cells10102513Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next FrontierRuiyi Zhang0Mengzhou Xue1Voon Wee Yong2The Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB T3A 4X9, CanadaThe Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, ChinaThe Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, AB T3A 4X9, CanadaDespite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.https://www.mdpi.com/2073-4409/10/10/2513intracerebral hemorrhagetissue regenerationneurogenesisremyelinationangiogenesisneuroinflammation |
| spellingShingle | Ruiyi Zhang Mengzhou Xue Voon Wee Yong Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier Cells intracerebral hemorrhage tissue regeneration neurogenesis remyelination angiogenesis neuroinflammation |
| title | Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier |
| title_full | Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier |
| title_fullStr | Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier |
| title_full_unstemmed | Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier |
| title_short | Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier |
| title_sort | central nervous system tissue regeneration after intracerebral hemorrhage the next frontier |
| topic | intracerebral hemorrhage tissue regeneration neurogenesis remyelination angiogenesis neuroinflammation |
| url | https://www.mdpi.com/2073-4409/10/10/2513 |
| work_keys_str_mv | AT ruiyizhang centralnervoussystemtissueregenerationafterintracerebralhemorrhagethenextfrontier AT mengzhouxue centralnervoussystemtissueregenerationafterintracerebralhemorrhagethenextfrontier AT voonweeyong centralnervoussystemtissueregenerationafterintracerebralhemorrhagethenextfrontier |