Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications
In this study, we highlight hydrogels prepared by electron-beam polymerization. In general, the electron-beam-polymerized hydrogels showed improved mechanical and optical transmittances compared to the conventional UV-cured hydrogels. They were more elastic and had a higher crosslinking density. Add...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Polymers |
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| Online Access: | http://www.mdpi.com/2073-4360/11/3/501 |
| _version_ | 1811277265390010368 |
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| author | Sarah Glass Mathias Kühnert Bernd Abel Agnes Schulze |
| author_facet | Sarah Glass Mathias Kühnert Bernd Abel Agnes Schulze |
| author_sort | Sarah Glass |
| collection | DOAJ |
| description | In this study, we highlight hydrogels prepared by electron-beam polymerization. In general, the electron-beam-polymerized hydrogels showed improved mechanical and optical transmittances compared to the conventional UV-cured hydrogels. They were more elastic and had a higher crosslinking density. Additionally, they were transparent over a broader wavelength range. The dependence of the mechanical and optical properties of the hydrogels on the number of single differential and total irradiation doses was analyzed in detail. The hydrogels were prepared for usage as a drug delivery material with methylene blue as a drug model. In the first set of experiments, methylene blue was loaded reversibly after the hydrogel synthesis. Electron-beam-polymerized hydrogels incorporated twice as much methylene blue compared to the UV-polymerized gels. Furthermore, the release of the model drug was found to depend on the crosslinking degree of the hydrogels. In addition, electron-beam polymerization enabled the irreversible binding of the drug molecules if they were mixed with monomers before polymerization. |
| first_indexed | 2024-04-13T00:13:41Z |
| format | Article |
| id | doaj.art-7edae37f852a4640bd03a3587378e471 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-13T00:13:41Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-7edae37f852a4640bd03a3587378e4712022-12-22T03:11:01ZengMDPI AGPolymers2073-43602019-03-0111350110.3390/polym11030501polym11030501Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery ApplicationsSarah Glass0Mathias Kühnert1Bernd Abel2Agnes Schulze3Leibniz Institute of Surface Engineering (IOM), Permoserstraße 15, D-04318 Leipzig, GermanyLeibniz Institute of Surface Engineering (IOM), Permoserstraße 15, D-04318 Leipzig, GermanyLeibniz Institute of Surface Engineering (IOM), Permoserstraße 15, D-04318 Leipzig, GermanyLeibniz Institute of Surface Engineering (IOM), Permoserstraße 15, D-04318 Leipzig, GermanyIn this study, we highlight hydrogels prepared by electron-beam polymerization. In general, the electron-beam-polymerized hydrogels showed improved mechanical and optical transmittances compared to the conventional UV-cured hydrogels. They were more elastic and had a higher crosslinking density. Additionally, they were transparent over a broader wavelength range. The dependence of the mechanical and optical properties of the hydrogels on the number of single differential and total irradiation doses was analyzed in detail. The hydrogels were prepared for usage as a drug delivery material with methylene blue as a drug model. In the first set of experiments, methylene blue was loaded reversibly after the hydrogel synthesis. Electron-beam-polymerized hydrogels incorporated twice as much methylene blue compared to the UV-polymerized gels. Furthermore, the release of the model drug was found to depend on the crosslinking degree of the hydrogels. In addition, electron-beam polymerization enabled the irreversible binding of the drug molecules if they were mixed with monomers before polymerization.http://www.mdpi.com/2073-4360/11/3/501electron beampolymerizationhydrogelsPEDGAcrosslinking degreedrug delivery |
| spellingShingle | Sarah Glass Mathias Kühnert Bernd Abel Agnes Schulze Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications Polymers electron beam polymerization hydrogels PEDGA crosslinking degree drug delivery |
| title | Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications |
| title_full | Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications |
| title_fullStr | Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications |
| title_full_unstemmed | Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications |
| title_short | Controlled Electron-Beam Synthesis of Transparent Hydrogels for Drug Delivery Applications |
| title_sort | controlled electron beam synthesis of transparent hydrogels for drug delivery applications |
| topic | electron beam polymerization hydrogels PEDGA crosslinking degree drug delivery |
| url | http://www.mdpi.com/2073-4360/11/3/501 |
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