Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study
Abstract Background There is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is important. The purpose of this study is to investigate if changes in physica...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | European Review of Aging and Physical Activity |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11556-023-00328-1 |
| _version_ | 1797577517462192128 |
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| author | Maren Lerfald Stian Lydersen Ekaterina Zotcheva Tom I. L. Nilsen Rannveig S. Eldholm Nicolas Martinez-Velilla Geir Selbæk Linda Ernstsen |
| author_facet | Maren Lerfald Stian Lydersen Ekaterina Zotcheva Tom I. L. Nilsen Rannveig S. Eldholm Nicolas Martinez-Velilla Geir Selbæk Linda Ernstsen |
| author_sort | Maren Lerfald |
| collection | DOAJ |
| description | Abstract Background There is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is important. The purpose of this study is to investigate if changes in physical activity (PA) in combinations with systolic blood pressure (SBP) trajectories in mid to late life are related to development of dementia in older age. Methods This prospective cohort study uses data from four consecutive surveys of the HUNT Study, Norway. Dementia was assessed in the HUNT4 70 + sub-study (2017–19). Group-based trajectory modelling identified three SBP trajectories from HUNT1 (1984–86) to HUNT3 (2006–2008): low, middle, and high. Change in PA was categorized into four groups based on high or low PA level at HUNT1 and HUNT3 and were combined with the SBP trajectories resulting in 12 distinct categories. Logistic regression was used to estimate odds ratios (ORs) of dementia. Results A total of 8487 participants (55% women, mean age (SD) 44.8 (6.5) years at HUNT1) were included. At HUNT4 70 + , 15.2% had dementia. We observed an overall decrease in OR of dementia across the PA/SBP categories when ranked from low to high PA (OR, 0.96; 95% CI, 0.93 to 1.00, P = 0.04). Within PA groups, a low SBP trajectory was associated with lower OR for dementia, apart from those with decreasing PA. The strongest association was observed for people with stable high PA and low SBP trajectory (OR, 0.38; 95% confidence interval (CI), 0.13 to 1.10 and adjusted risk difference, -8.34 percentage points; 95% CI, -15.32 to -1.36). Conclusion Our findings illustrate the clinical importance of PA and SBP for dementia prevention and that favorable levels of both are associated with reduced occurrence of dementia. |
| first_indexed | 2024-03-10T22:09:26Z |
| format | Article |
| id | doaj.art-7edb33555d68498ebbb3fe8b795eb10a |
| institution | Directory Open Access Journal |
| issn | 1861-6909 |
| language | English |
| last_indexed | 2024-03-10T22:09:26Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | European Review of Aging and Physical Activity |
| spelling | doaj.art-7edb33555d68498ebbb3fe8b795eb10a2023-11-19T12:40:49ZengBMCEuropean Review of Aging and Physical Activity1861-69092023-10-0120111010.1186/s11556-023-00328-1Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT studyMaren Lerfald0Stian Lydersen1Ekaterina Zotcheva2Tom I. L. Nilsen3Rannveig S. Eldholm4Nicolas Martinez-Velilla5Geir Selbæk6Linda Ernstsen7Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and TechnologyDepartment of Mental Health, Faculty of Medicine and Health Science, Norwegian University of Science and TechnologyNorwegian National Centre for Ageing and Health, Vestfold Hospital TrustDepartment of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and TechnologyDepartment of Geriatrics, Clinic of Medicine, St.Olavs HospitalNavarrabiomed, Hospital Universitario de Navarra, UPNA, IdiSNANorwegian National Centre for Ageing and Health, Vestfold Hospital TrustDepartment of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and TechnologyAbstract Background There is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is important. The purpose of this study is to investigate if changes in physical activity (PA) in combinations with systolic blood pressure (SBP) trajectories in mid to late life are related to development of dementia in older age. Methods This prospective cohort study uses data from four consecutive surveys of the HUNT Study, Norway. Dementia was assessed in the HUNT4 70 + sub-study (2017–19). Group-based trajectory modelling identified three SBP trajectories from HUNT1 (1984–86) to HUNT3 (2006–2008): low, middle, and high. Change in PA was categorized into four groups based on high or low PA level at HUNT1 and HUNT3 and were combined with the SBP trajectories resulting in 12 distinct categories. Logistic regression was used to estimate odds ratios (ORs) of dementia. Results A total of 8487 participants (55% women, mean age (SD) 44.8 (6.5) years at HUNT1) were included. At HUNT4 70 + , 15.2% had dementia. We observed an overall decrease in OR of dementia across the PA/SBP categories when ranked from low to high PA (OR, 0.96; 95% CI, 0.93 to 1.00, P = 0.04). Within PA groups, a low SBP trajectory was associated with lower OR for dementia, apart from those with decreasing PA. The strongest association was observed for people with stable high PA and low SBP trajectory (OR, 0.38; 95% confidence interval (CI), 0.13 to 1.10 and adjusted risk difference, -8.34 percentage points; 95% CI, -15.32 to -1.36). Conclusion Our findings illustrate the clinical importance of PA and SBP for dementia prevention and that favorable levels of both are associated with reduced occurrence of dementia.https://doi.org/10.1186/s11556-023-00328-1Physical activityBlood pressureTrajectoriesDementia |
| spellingShingle | Maren Lerfald Stian Lydersen Ekaterina Zotcheva Tom I. L. Nilsen Rannveig S. Eldholm Nicolas Martinez-Velilla Geir Selbæk Linda Ernstsen Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study European Review of Aging and Physical Activity Physical activity Blood pressure Trajectories Dementia |
| title | Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study |
| title_full | Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study |
| title_fullStr | Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study |
| title_full_unstemmed | Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study |
| title_short | Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study |
| title_sort | change in physical activity and systolic blood pressure trajectories throughout mid life and the development of dementia in older age the hunt study |
| topic | Physical activity Blood pressure Trajectories Dementia |
| url | https://doi.org/10.1186/s11556-023-00328-1 |
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