Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway

Essential oil from the roots of Paeonia lactiflora pall. has protective effect against corticosterone-induced depression in mice via modulation of PI3K/Akt signaling pathway

For thousands of years, the roots of Paeonia lactiflora Pall (PLP) has been considered by traditional Chinese medicine as a drug that can improve mental or emotional disorders, including depression, anxiety and affective disorders. Unfortunately, the research on the mechanism of action and active in...

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Bibliographic Details
Main Authors: Jia-Yi Sun, Yi-Tong Liu, Sheng-Nan Jiang, Peng-Mei Guo, Xin-Yu Wu, Jia Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
depression
apoptosis
PI3K-Akt pathway
oxidative stress
neuroprotection
experimental techniques
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.999712/full

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