p53 and MDM2 protein expression in actinic cheilitis
Actinic cheilitis is a potentially malignant lip lesion caused by excessive and prolonged exposure to ultraviolet radiation, which can lead to histomorphological alterations indicative of abnormal cell differentiation. In this pathology, varying degrees of epithelial dysplasia may be found. There ar...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2008-12-01
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| Series: | Journal of Applied Oral Science |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000600011 |
| _version_ | 1818050833086939136 |
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| author | Maria da Conceição Andrade de Freitas Luciana Maria Pedreira Ramalho Flávia Caló Aquino Xavier André Luis Gomes Moreira Sílvia Regina Almeida Reis |
| author_facet | Maria da Conceição Andrade de Freitas Luciana Maria Pedreira Ramalho Flávia Caló Aquino Xavier André Luis Gomes Moreira Sílvia Regina Almeida Reis |
| author_sort | Maria da Conceição Andrade de Freitas |
| collection | DOAJ |
| description | Actinic cheilitis is a potentially malignant lip lesion caused by excessive and prolonged exposure to ultraviolet radiation, which can lead to histomorphological alterations indicative of abnormal cell differentiation. In this pathology, varying degrees of epithelial dysplasia may be found. There are few published studies regarding the p53 and MDM2 proteins in actinic cheilitis. Fifty-eight cases diagnosed with actinic cheilitis were histologically evaluated using Banóczy and Csiba (1976) parameters, and were subjected to immunohistochemical analysis using the streptavidin-biotin method in order to assess p53 and MDM2 protein expression. All studied cases expressed p53 proteins in basal and suprabasal layers. In the basal layer, the nuclei testing positive for p53 were stained intensely, while in the suprabasal layer, cells with slightly stained nuclei were predominant. All cases also tested positive for the MDM2 protein, but with varying degrees of nuclear expression and a predominance of slightly stained cells. A statistically significant correlation between the percentage of p53 and MDM2-positive cells was established, regardless of the degree of epithelial dysplasia. The expression of p53 and MDM2 proteins in actinic cheilitis can be an important indicator in lip carcinogenesis, regardless of the degree of epithelial dysplasia. |
| first_indexed | 2024-12-10T10:59:45Z |
| format | Article |
| id | doaj.art-7edc6c26db8a4b40aa79cc7059db616b |
| institution | Directory Open Access Journal |
| issn | 1678-7757 1678-7765 |
| language | English |
| last_indexed | 2024-12-10T10:59:45Z |
| publishDate | 2008-12-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Journal of Applied Oral Science |
| spelling | doaj.art-7edc6c26db8a4b40aa79cc7059db616b2022-12-22T01:51:44ZengUniversity of São PauloJournal of Applied Oral Science1678-77571678-77652008-12-0116641441910.1590/S1678-77572008000600011p53 and MDM2 protein expression in actinic cheilitisMaria da Conceição Andrade de FreitasLuciana Maria Pedreira RamalhoFlávia Caló Aquino XavierAndré Luis Gomes MoreiraSílvia Regina Almeida ReisActinic cheilitis is a potentially malignant lip lesion caused by excessive and prolonged exposure to ultraviolet radiation, which can lead to histomorphological alterations indicative of abnormal cell differentiation. In this pathology, varying degrees of epithelial dysplasia may be found. There are few published studies regarding the p53 and MDM2 proteins in actinic cheilitis. Fifty-eight cases diagnosed with actinic cheilitis were histologically evaluated using Banóczy and Csiba (1976) parameters, and were subjected to immunohistochemical analysis using the streptavidin-biotin method in order to assess p53 and MDM2 protein expression. All studied cases expressed p53 proteins in basal and suprabasal layers. In the basal layer, the nuclei testing positive for p53 were stained intensely, while in the suprabasal layer, cells with slightly stained nuclei were predominant. All cases also tested positive for the MDM2 protein, but with varying degrees of nuclear expression and a predominance of slightly stained cells. A statistically significant correlation between the percentage of p53 and MDM2-positive cells was established, regardless of the degree of epithelial dysplasia. The expression of p53 and MDM2 proteins in actinic cheilitis can be an important indicator in lip carcinogenesis, regardless of the degree of epithelial dysplasia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000600011CheilitisImmunohistochemistryp53MDM2 protein |
| spellingShingle | Maria da Conceição Andrade de Freitas Luciana Maria Pedreira Ramalho Flávia Caló Aquino Xavier André Luis Gomes Moreira Sílvia Regina Almeida Reis p53 and MDM2 protein expression in actinic cheilitis Journal of Applied Oral Science Cheilitis Immunohistochemistry p53 MDM2 protein |
| title | p53 and MDM2 protein expression in actinic cheilitis |
| title_full | p53 and MDM2 protein expression in actinic cheilitis |
| title_fullStr | p53 and MDM2 protein expression in actinic cheilitis |
| title_full_unstemmed | p53 and MDM2 protein expression in actinic cheilitis |
| title_short | p53 and MDM2 protein expression in actinic cheilitis |
| title_sort | p53 and mdm2 protein expression in actinic cheilitis |
| topic | Cheilitis Immunohistochemistry p53 MDM2 protein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572008000600011 |
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