Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, rand...
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| Format: | Article |
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MDPI AG
2017-08-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/9/8/253 |
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| author | Bo Young Hong Hyun Jung Chang Sang-Jee Lee Soyoung Lee Joo Hyun Park Jeong-Yi Kwon |
| author_facet | Bo Young Hong Hyun Jung Chang Sang-Jee Lee Soyoung Lee Joo Hyun Park Jeong-Yi Kwon |
| author_sort | Bo Young Hong |
| collection | DOAJ |
| description | Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, randomized, prospective phase III clinical trial of botulinum toxin A for the treatment of dynamic equinus in 144 children with cerebral palsy was performed to compare the efficacies of letibotulinumtoxin A and onabotulinumtoxin A. Secondary analyses were performed to evaluate factors that affected the outcome, focusing on the number of times injections were repeated. Effectiveness was defined as a change of 2 or more in the physician’s rating scale. Multivariate regression analyses were performed with multiple variables. The first injection of botulinum toxin A significantly improved D subscale of Gross Motor Function Measure-88 scores at 3 months compared to repeated injections (p < 0.05). After 6 months, patients who had one injection or none before the study showed significantly better outcomes than those who had more than one injection in terms of observational gait scores. |
| first_indexed | 2024-04-11T13:39:55Z |
| format | Article |
| id | doaj.art-7edcdc9d83874373b0d5a5295f219bf5 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T13:39:55Z |
| publishDate | 2017-08-01 |
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| record_format | Article |
| series | Toxins |
| spelling | doaj.art-7edcdc9d83874373b0d5a5295f219bf52022-12-22T04:21:17ZengMDPI AGToxins2072-66512017-08-019825310.3390/toxins9080253toxins9080253Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical TrialBo Young Hong0Hyun Jung Chang1Sang-Jee Lee2Soyoung Lee3Joo Hyun Park4Jeong-Yi Kwon5Department of Rehabilitation Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, South KoreaDepartment of Physical Medicine & Rehabilitation, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 51353, South KoreaDepartment of Rehabilitation Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, South KoreaDepartment of Physical Medicine & Rehabilitation, Keimyung University, Dongsan Medical Center, Daegu 41931, South KoreaDepartment of Rehabilitation Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, South KoreaDepartment of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South KoreaBotulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, randomized, prospective phase III clinical trial of botulinum toxin A for the treatment of dynamic equinus in 144 children with cerebral palsy was performed to compare the efficacies of letibotulinumtoxin A and onabotulinumtoxin A. Secondary analyses were performed to evaluate factors that affected the outcome, focusing on the number of times injections were repeated. Effectiveness was defined as a change of 2 or more in the physician’s rating scale. Multivariate regression analyses were performed with multiple variables. The first injection of botulinum toxin A significantly improved D subscale of Gross Motor Function Measure-88 scores at 3 months compared to repeated injections (p < 0.05). After 6 months, patients who had one injection or none before the study showed significantly better outcomes than those who had more than one injection in terms of observational gait scores.https://www.mdpi.com/2072-6651/9/8/253cerebral palsyspasticitybotulinum toxinonabotulinumtoxin Aletibotulinumtoxin Aequinus |
| spellingShingle | Bo Young Hong Hyun Jung Chang Sang-Jee Lee Soyoung Lee Joo Hyun Park Jeong-Yi Kwon Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial Toxins cerebral palsy spasticity botulinum toxin onabotulinumtoxin A letibotulinumtoxin A equinus |
| title | Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial |
| title_full | Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial |
| title_fullStr | Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial |
| title_full_unstemmed | Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial |
| title_short | Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial |
| title_sort | efficacy of repeated botulinum toxin type a injections for spastic equinus in children with cerebral palsy a secondary analysis of the randomized clinical trial |
| topic | cerebral palsy spasticity botulinum toxin onabotulinumtoxin A letibotulinumtoxin A equinus |
| url | https://www.mdpi.com/2072-6651/9/8/253 |
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