Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation
Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is still limited. This limitation is already caused by...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/9/5/100 |
| _version_ | 1811267082086514688 |
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| author | Stefanie Linnhoff Marina Fiene Hans-Jochen Heinze Tino Zaehle |
| author_facet | Stefanie Linnhoff Marina Fiene Hans-Jochen Heinze Tino Zaehle |
| author_sort | Stefanie Linnhoff |
| collection | DOAJ |
| description | Cognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is still limited. This limitation is already caused by an inconsistent and heterogeneous terminology and assessment of fatigue. In this review, we integrate previous literature on fatigue and propose a unified schema aiming to clarify the fatigue taxonomy. With special focus on cognitive fatigue, we survey the significance of objective behavioral and electrophysiological fatigue parameters and discuss the controversial literature on the relationship between subjective and objective fatigue assessment. As MS-related cognitive fatigue drastically affects quality of life, the development of efficient therapeutic approaches for overcoming cognitive fatigue is of high clinical relevance. In this regard, the reliable and valid assessment of the individual fatigue level by objective parameters is essential for systematic treatment evaluation and optimization. Transcranial electrical stimulation (tES) may offer a unique opportunity to manipulate maladaptive neural activity underlying MS fatigue. Therefore, we discuss evidence for the therapeutic potential of tES on cognitive fatigue in people with MS. |
| first_indexed | 2024-04-12T20:54:48Z |
| format | Article |
| id | doaj.art-7edd4fd0493d4ad88a65ce6e0fa919a8 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-12T20:54:48Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-7edd4fd0493d4ad88a65ce6e0fa919a82022-12-22T03:17:01ZengMDPI AGBrain Sciences2076-34252019-05-019510010.3390/brainsci9050100brainsci9050100Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical StimulationStefanie Linnhoff0Marina Fiene1Hans-Jochen Heinze2Tino Zaehle3Department of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Street 44, Magdeburg 39120, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg 20246, GermanyDepartment of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Street 44, Magdeburg 39120, GermanyDepartment of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Street 44, Magdeburg 39120, GermanyCognitive fatigue is one of the most frequent symptoms in multiple sclerosis (MS), associated with significant impairment in daily functioning and quality of life. Despite its clinical significance, progress in understanding and treating fatigue is still limited. This limitation is already caused by an inconsistent and heterogeneous terminology and assessment of fatigue. In this review, we integrate previous literature on fatigue and propose a unified schema aiming to clarify the fatigue taxonomy. With special focus on cognitive fatigue, we survey the significance of objective behavioral and electrophysiological fatigue parameters and discuss the controversial literature on the relationship between subjective and objective fatigue assessment. As MS-related cognitive fatigue drastically affects quality of life, the development of efficient therapeutic approaches for overcoming cognitive fatigue is of high clinical relevance. In this regard, the reliable and valid assessment of the individual fatigue level by objective parameters is essential for systematic treatment evaluation and optimization. Transcranial electrical stimulation (tES) may offer a unique opportunity to manipulate maladaptive neural activity underlying MS fatigue. Therefore, we discuss evidence for the therapeutic potential of tES on cognitive fatigue in people with MS.https://www.mdpi.com/2076-3425/9/5/100cognitive fatiguemultiple sclerosisobjective measurementfatigabilitytDCStACS |
| spellingShingle | Stefanie Linnhoff Marina Fiene Hans-Jochen Heinze Tino Zaehle Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation Brain Sciences cognitive fatigue multiple sclerosis objective measurement fatigability tDCS tACS |
| title | Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation |
| title_full | Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation |
| title_fullStr | Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation |
| title_full_unstemmed | Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation |
| title_short | Cognitive Fatigue in Multiple Sclerosis: An Objective Approach to Diagnosis and Treatment by Transcranial Electrical Stimulation |
| title_sort | cognitive fatigue in multiple sclerosis an objective approach to diagnosis and treatment by transcranial electrical stimulation |
| topic | cognitive fatigue multiple sclerosis objective measurement fatigability tDCS tACS |
| url | https://www.mdpi.com/2076-3425/9/5/100 |
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